Regioselective copper(I)-catalyzed ullmann amination of halopyridyl carboxylates using sodium azide: a route for aminopyridyl carboxylates and their transformation to pyrido[2, 3-d]pyrimidin-4(1H)-ones

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dc.citation.epage4826en_US
dc.citation.issueNumber17en_US
dc.citation.spage4822en_US
dc.citation.volumeNumber3en_US
dc.contributor.authorNishaen_US
dc.contributor.authorSharma, Mr. C.en_US
dc.contributor.authorKumar, R.en_US
dc.contributor.authorKumar, Y.en_US
dc.date.accessioned2019-02-21T16:03:05Z
dc.date.available2019-02-21T16:03:05Z
dc.date.issued2018en_US
dc.departmentNanotechnology Research Center (NANOTAM)en_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.departmentDepartment of Chemistryen_US
dc.description.abstractWe report herein an efficient, straightforward and ligand free synthesis of aminopyridyl carboxylates, an important building block used in pharmaceuticals and agrochemicals. The C(sp2)-N bond formation utilize a readily available Cu-catalyst, NaN3 as the amino source in ethanol, and the corresponding ortho-functionalized aromatic amines were synthesized in good to excellent yields. This ligand free one-pot domino methodology proceeds through Ullmann-type coupling of halopyridyl carboxylates with sodium azide followed by reduction with ethanol. These functionalized aminopyridyl carboxylates provides an easy access to biologically potent pyrido[2, 3-d]pyrimidin-4(1H)-one hybrids.
dc.embargo.release2019-05-08en_US
dc.identifier.doi10.1002/slct.201800907
dc.identifier.eissn2365-6549
dc.identifier.urihttp://hdl.handle.net/11693/50073
dc.language.isoEnglish
dc.publisherWiley-Blackwell
dc.relation.isversionofhttps://doi.org/10.1002/slct.201800907
dc.source.titleChemistrySelecten_US
dc.subjectAminationen_US
dc.subjectCopper-catalyzed reactionen_US
dc.subjectNicotinamideen_US
dc.subjectNicotinic aciden_US
dc.subjectUllmann couplingen_US
dc.titleRegioselective copper(I)-catalyzed ullmann amination of halopyridyl carboxylates using sodium azide: a route for aminopyridyl carboxylates and their transformation to pyrido[2, 3-d]pyrimidin-4(1H)-onesen_US
dc.typeArticleen_US

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Nanotechnology Research Center (NANOTAM)
Department of Chemistry
Institute of Materials Science and Nanotechnology (UNAM)