Effect of patient sex on white matter alterations in unilateral medial temporal lobe epilepsy with hippocampal sclerosis assessed by diffusion tensor imaging

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dc.citation.epage1015en_US
dc.citation.issueNumber5en_US
dc.citation.spage1010en_US
dc.citation.volumeNumber34en_US
dc.contributor.authorOguz, K.K.en_US
dc.contributor.authorTezer I.en_US
dc.contributor.authorSanverdi, E.en_US
dc.contributor.authorHas, A.C.en_US
dc.contributor.authorBilginer, B.en_US
dc.contributor.authorDolgun, A.en_US
dc.contributor.authorSaygi, S.en_US
dc.date.accessioned2016-02-08T09:39:00Z
dc.date.available2016-02-08T09:39:00Z
dc.date.issued2013en_US
dc.departmentNanotechnology Research Center (NANOTAM)en_US
dc.description.abstractBACKGROUND AND PURPOSE: Studies shows ictal behavior and symptoms are affected by patient sex in temporal lobe epilepsy. The purpose of our study was to determine whether alterations in the WM as assessed by DTI display different patterns in male and female patients with unilateral HS. MATERIALS AND METHODS: Patients with unilateral HS were categorized as women with right HS ( n=12), men with right HS ( n=10), women with left HS ( n=12), and men with left HS ( n=10). DTI of the brain along 64 noncollinear directions was obtained from 44 patients and 37 sex-matched control participants. We used TBSS to analyze whole-brain WM. Regions with significant changes of FA and MD, and their mean FA, MD, total number of significant voxels, and asymmetry indices were determined for each group. RESULTS: All groups showed bilateral and extensive reductions of FA and elevated MD in the WM, more prominent ipsilateral to the affected hippocampus. The total number of voxels with decreased FA in patients compared with that of control participants was higher in women with right HS (24,727 vs 5,459) and in men with left HS (27,332 vs 14,013) than in their counterparts. Changes in MD associated with right HS were more extensive in both men and women (right vs left HS, women: 16,926 vs 5,458; men: 5,389 vs 4,764) than in those with left HS. In patients with right HS, the ipsilateral cingulum, uncinate fasciculus, internal and external capsules, and right acoustic radiation were involved extensively in women. CONCLUSIONS: Women and men showed different patterns in extent of WM alterations associated with HS.en_US
dc.description.provenanceMade available in DSpace on 2016-02-08T09:39:00Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 70227 bytes, checksum: 26e812c6f5156f83f0e77b261a471b5a (MD5) Previous issue date: 2013en
dc.identifier.doi10.3174/ajnr.A3328en_US
dc.identifier.issn1956108
dc.identifier.urihttp://hdl.handle.net/11693/20978
dc.language.isoEnglishen_US
dc.relation.isversionofhttp://dx.doi.org/10.3174/ajnr.A3328en_US
dc.source.titleAmerican Journal of Neuroradiologyen_US
dc.subjectadulten_US
dc.subjectarticleen_US
dc.subjectbrainen_US
dc.subjectcapsula internaen_US
dc.subjectclinical articleen_US
dc.subjectcontrolled studyen_US
dc.subjectdiffusion tensor imagingen_US
dc.subjectexternal capsuleen_US
dc.subjectfemaleen_US
dc.subjecthippocampal sclerosisen_US
dc.subjecthippocampusen_US
dc.subjecthumanen_US
dc.subjectmaleen_US
dc.subjectneuroimagingen_US
dc.subjectsex differenceen_US
dc.subjecttemporal lobe epilepsyen_US
dc.subjectuncinate fasciculusen_US
dc.subjectvoxel based morphometryen_US
dc.subjectwhite matteren_US
dc.subjectAdulten_US
dc.subjectDiffusion Magnetic Resonance Imagingen_US
dc.subjectEpilepsy, Temporal Lobeen_US
dc.subjectFemaleen_US
dc.subjectHippocampusen_US
dc.subjectHumansen_US
dc.subjectMaleen_US
dc.subjectNerve Fibers, Myelinateden_US
dc.subjectPrevalenceen_US
dc.subjectReproducibility of Resultsen_US
dc.subjectRisk Assessmenten_US
dc.subjectSclerosisen_US
dc.subjectSensitivity and Specificityen_US
dc.subjectSex Distributionen_US
dc.subjectTurkeyen_US
dc.titleEffect of patient sex on white matter alterations in unilateral medial temporal lobe epilepsy with hippocampal sclerosis assessed by diffusion tensor imagingen_US
dc.typeArticleen_US

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