Design of a hybrid magnetic fluid hyperthermia and magnetic particle spectrometer setup

Abstract

Magnetic particle imaging (MPI) enables cancer imaging via enhanced permeability and retention effect that causes magnetic nanoparticles (MNPs) to accumulate in cancerous tissue, or via determining the change in MNP signal due to increased viscosity in cancerous tissue. MPI can also enable localization of magnetic fluid hyperthermia (MFH) therapy to a targeted region to locally heat up the MNPs and cause the death of cancerous tissue. However, the heating should be kept under control so that the nearby healthy tissue is spared. Hybrid MFH-MPI systems have the potential to enable real-time non-invasive temperature monitoring for hyperthermia therapy via the relaxation response of MNPs. Here, we present the design and simulation results of a hybrid MFH and magnetic particle spectrometer (MPS) setup. This hybrid design is composed of three coaxial coils with gradiometric windings to minimize the mutual inductances among all three coils.