Photosensitizers for photodynamic action and synthesis of modules for a molecular demultiplexer

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buir.advisorAkkaya, Engin U.
dc.contributor.authorDurgut, Tuğçe
dc.date.accessioned2016-01-08T20:18:28Z
dc.date.available2016-01-08T20:18:28Z
dc.date.issued2014
dc.descriptionAnkara : The Department of Chemistry and the Graduate School of Engineering and Science of Bilkent University, 2014.en_US
dc.descriptionThesis (Master's) -- Bilkent University, 2014.en_US
dc.descriptionIncludes bibliographical references leaves 53-61.en_US
dc.description.abstractPhotodynamic therapy (PDT) is a new therapeutic methodology that uses light as a distinguishing tool for the treatment of diseased cells. In recent years PDT has become one of the most preferred therapies because it is innocent for the healthy cells and tissues while diagnosing and curing the malignant cells and tissues. Bodipy is one of the most favorite fluorophore in this field due to its excellent chemical and physical properties. Logic gates are widely used in modern technology as the fundamentals of logical operations for the development of science. The progressive advances leads to the emergence and growth of molecular logic gates. Molecular logic gates can be used for the diagnosis and therapies of disease which are originated from the heredity. In addition, they occupy an important place in the theoretical and practical use of photodynamic therapy. In the first part of my thesis, we designed and synthesized a calix[4]arene-Bodipy conjugate molecule as a carrier for the photodynamic therapy agents. It is an amphiphilic delivery molecule that is utilized for the curing of tumor tissues. In the second part, we synthesized modules for molecular logic gate function, DEMUX (demultiplexer), serving as a theranostic device which selects either singlet oxygen channel or energy transfer between the modules depending on the inputs. The superiority of the project is that it serves a realistic pathway for the PDT.en_US
dc.description.provenanceMade available in DSpace on 2016-01-08T20:18:28Z (GMT). No. of bitstreams: 1 1.pdf: 78510 bytes, checksum: d85492f20c2362aa2bcf4aad49380397 (MD5)en
dc.description.statementofresponsibilityDurgut, Tuğçeen_US
dc.embargo.release2016-09-01
dc.format.extentxiii, 84 leaves, charts, platesen_US
dc.identifier.itemidB148292
dc.identifier.urihttp://hdl.handle.net/11693/18348
dc.language.isoEnglishen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCalixarenesen_US
dc.subjectLogic gatesen_US
dc.subjectPhotodynamic therapyen_US
dc.subjectDemultiplexeren_US
dc.subject.lccQZ267 .D87 2014en_US
dc.subject.lcshPhotochemotherapy.en_US
dc.subject.lcshPhototherapy.en_US
dc.titlePhotosensitizers for photodynamic action and synthesis of modules for a molecular demultiplexeren_US
dc.typeThesisen_US
thesis.degree.disciplineChemistry
thesis.degree.grantorBilkent University
thesis.degree.levelMaster's
thesis.degree.nameMS (Master of Science)

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