Discovering modulators of gene expression
Date
2010-09-01
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Abstract
Proteins that modulate the activity of transcription factors, often called modulators, play a critical role in creating tissue- and context-specific gene expression responses to the signals cells receive. GEM (Gene Expression Modulation) is a probabilistic framework that predicts modulators, their affected targets and mode of action by combining gene expression profiles, protein-protein interactions and transcription factor-target relationships. Using GEM, we correctly predicted a significant number of androgen receptor modulators and observed that most modulators can both act as co-activators and co-repressors for different target genes. © The Author(s) 2010. Published by Oxford University Press.
Source Title
Nucleic Acids Research
Publisher
Oxford University Press
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Androgen receptor, Transcription factor, Gene activation, Gene expression profiling, Gene expression regulation, Gene repression, Gene targeting, Priority journal, Probability, Protein function, Statistical analysis, Biological model, Evaluation study, Genetic transcription, Metabolism, Protein analysis
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English