Nanofabrication and plasma polymerization assisted surface modification of a transducer based on localized surface plasmon resonance of gold nanostructure arrays for biosensor applications

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buir.contributor.authorÖzbay, Ekmel
buir.contributor.orcidÖzbay, Ekmel|0000-0003-2953-1828
dc.citation.epage061602-12en_US
dc.citation.issueNumber1en_US
dc.citation.spage061602-1en_US
dc.citation.volumeNumber6en_US
dc.contributor.authorTurhan, A. B.en_US
dc.contributor.authorAtaman, D.en_US
dc.contributor.authorSen, Y.en_US
dc.contributor.authorMutlu, M.en_US
dc.contributor.authorÖzbay, Ekmelen_US
dc.date.accessioned2015-07-28T12:01:07Z
dc.date.available2015-07-28T12:01:07Z
dc.date.issued2012-07-31en_US
dc.departmentDepartment of Physicsen_US
dc.departmentDepartment of Electrical and Electronics Engineeringen_US
dc.description.abstractThe nanofabrication and surface modification of a transducer based on localized surface plasmon resonance (LSPR) of gold nanostructure arrays for biosensing was studied. We used electron beam lithography for the nanopatterning technique, which let us choose LSPR sensor properties by providing immense control over nanostructural geometry. A critical step in the utilization of this transducer is to form a selective biolayer over the gold nanostructures. We applied plasma polymerization and wet chemistry techniques for ethylenediamine (EDA) modification and glutaraldehyde immobilization as intermediate layers, respectively. The gold nanostructure arrays were primarily modified using EDA in order to activate the surface with amine groups that are cross-linked with later added avidin molecules by the help of glutaraldhyde layer residing in between. The success of plasma polymerization was validated with x-ray photoelectron spectroscopy measurements. As a last step, we introduced biotin to the surface (biotin has a high affinity for avidin). We were able to detect the LSPR resonance wavelength shift in the transmission spectra at each step of modification, including the avidin-biotin interaction, which acts as a model for specific molecule detection using LSPR. (C) 2012 Society of Photo-Optical Instrumentation Engineers (SPIE).en_US
dc.description.provenanceMade available in DSpace on 2015-07-28T12:01:07Z (GMT). No. of bitstreams: 1 10.1117-1.JNP.6.061602.pdf: 4267264 bytes, checksum: 93d12a05a3e8294bb38d4788f4d48342 (MD5)en
dc.identifier.doi10.1117/1.JNP.6.061602en_US
dc.identifier.issn1934-2608
dc.identifier.urihttp://hdl.handle.net/11693/12358
dc.language.isoEnglishen_US
dc.publisherS P I E - International Society for Optical Engineeringen_US
dc.relation.isversionofhttp://dx.doi.org/10.1117/1.JNP.6.061602en_US
dc.source.titleJournal of Nanophotonicsen_US
dc.subjectLocalized surface plasmon resonanceen_US
dc.subjectElectron beam lithographyen_US
dc.subjectPlasma polymerizationen_US
dc.subjectTransduceren_US
dc.subjectBiosensoren_US
dc.titleNanofabrication and plasma polymerization assisted surface modification of a transducer based on localized surface plasmon resonance of gold nanostructure arrays for biosensor applicationsen_US
dc.typeArticleen_US

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