Cancer testis gene expression as a biomarker of one-carbon metabolic activity, drug sensitivity and phenotypic heterogeneity in non-small cell lung cancer and malignant melanoma

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buir.advisorGüre, Ali Osmay
dc.contributor.authorŞenses, Kerem Mert
dc.date.accessioned2016-09-20T13:43:35Z
dc.date.available2016-09-20T13:43:35Z
dc.date.copyright2016-09
dc.date.issued2016-09
dc.date.submitted2016-09-09
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.descriptionCataloged from PDF version of article.en_US
dc.descriptionThesis (Ph.D.): Bilkent University, Department of Molecular Biology and Genetics, İhsan Doğramacı Bilkent University, 2016.en_US
dc.descriptionIncludes bibliographical references (leaves 96-116).en_US
dc.description.abstractExpression of cancer-testis (CT) genes on X chromosome (CT-X) is restricted to tumors, with very low or no expression in normal adult tissues. CT-X gene expression is one of the factors contributing to tumor heterogeneity and is variably observed in various types of cancers including non-small cell lung cancer (NSCLC) and malignant melanoma. Regulation of CT-X gene expression has been strongly linked to DNA methylation of promoter regions, however, mechanisms leading to re-expression of these genes in tumors, driven by promoter hypomethylation, is remained unsolved. Although tumors expressing CT-X genes are shown to be associated with higher tumor stage, larger tumors and aggressiveness, differential drug sensitivity of CT-X positive and negative tumors have not been investigated. In this thesis, we aimed to find the association between one-carbon pathway polymorphisms and CT-X gene expression. Moreover, we tested various tools and methods to find effective drugs for tumors in different phenotypic subgroups determined by CT-X gene expression or by other factors.en_US
dc.description.degreePh.D.en_US
dc.description.statementofresponsibilityby Kerem Mert Şenses.en_US
dc.embargo.release2018-09-09
dc.format.extentxiv, 165 leaves : charts (some color)en_US
dc.identifier.itemidB154031
dc.identifier.urihttp://hdl.handle.net/11693/32244
dc.language.isoEnglishen_US
dc.publisherBilkent Universityen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCancer-testis genesen_US
dc.subjectDNA damageen_US
dc.subjectOne-carbon pathwayen_US
dc.subjectDrug sensitivityen_US
dc.subjectNSCLCen_US
dc.subjectMelanomaen_US
dc.subjectMicroarrayen_US
dc.titleCancer testis gene expression as a biomarker of one-carbon metabolic activity, drug sensitivity and phenotypic heterogeneity in non-small cell lung cancer and malignant melanomaen_US
dc.title.alternativeKüçük hücre dışı akciğer kanseri ve malin melanom’da tekkarbon metabolik yolağı aktivitesi, ilaç hassasiyeti ve fenotipik heterojenite’nin biyo-belirteci olarak kanser-testis gen ifadesien_US
dc.typeThesisen_US

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