Intracellular modulation of excited-state dynamics in a chromophore dyad: differential enhancement of photocytotoxicity targeting cancer cells

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dc.citation.epage5344en_US
dc.citation.issueNumber18en_US
dc.citation.spage5340en_US
dc.citation.volumeNumber54en_US
dc.contributor.authorKolemen, S.en_US
dc.contributor.authorIşık, M.en_US
dc.contributor.authorKim, G. M.en_US
dc.contributor.authorKim D.en_US
dc.contributor.authorGeng, H.en_US
dc.contributor.authorBuyuktemiz, M.en_US
dc.contributor.authorKaratas, T.en_US
dc.contributor.authorZhang, X. F.en_US
dc.contributor.authorDede, Y.en_US
dc.contributor.authorYoon, J.en_US
dc.contributor.authorAkkaya, E. U.en_US
dc.date.accessioned2016-02-08T09:54:56Z
dc.date.available2016-02-08T09:54:56Z
dc.date.issued2015en_US
dc.departmentDepartment of Chemistryen_US
dc.description.abstractThe photosensitized generation of reactive oxygen species, and particularly of singlet oxygen [O2(a1Dg)], is the essence of photodynamic action exploited in photodynamic therapy. The ability to switch singlet oxygen generation on/off would be highly valuable, especially when it is linked to a cancer-related cellular parameter. Building on recent findings related to intersystem crossing efficiency, we designed a dimeric BODIPY dye with reduced symmetry, which is ineffective as a photosensitizer unless it is activated by a reaction with intracellular glutathione (GSH). The reaction alters the properties of both the ground and excited states, consequently enabling the efficient generation of singlet oxygen. Remarkably, the designed photosensitizer can discriminate between different concentrations of GSH in normal and cancer cells and thus remains inefficient as a photosensitizer inside a normal cell while being transformed into a lethal singlet oxygen source in cancer cells. This is the first demonstration of such a difference in the intracellular activity of a photosensitizer.en_US
dc.description.provenanceMade available in DSpace on 2016-02-08T09:54:56Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 70227 bytes, checksum: 26e812c6f5156f83f0e77b261a471b5a (MD5) Previous issue date: 2015en
dc.identifier.doi10.1002/anie.201411962en_US
dc.identifier.eissn1521-3773
dc.identifier.issn1433-7851
dc.identifier.urihttp://hdl.handle.net/11693/22059
dc.language.isoEnglishen_US
dc.publisherWiley-VCH Verlagen_US
dc.relation.isversionofhttp://dx.doi.org/10.1002/anie.201411962en_US
dc.source.titleAngewandte Chemie (International Edition)en_US
dc.titleIntracellular modulation of excited-state dynamics in a chromophore dyad: differential enhancement of photocytotoxicity targeting cancer cellsen_US
dc.typeArticleen_US

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