Design, synthesis, and biological evaluation of indole-based 1,4-disubstituted piperazines as cytotoxic agents

Date
2012
Advisor
Instructor
Source Title
Turkish Journal of Chemistry
Print ISSN
1300-0527
Electronic ISSN
Publisher
Volume
36
Issue
4
Pages
515 - 525
Language
English
Type
Article
Journal Title
Journal ISSN
Volume Title
Abstract

A series of 3-[(4-substitutedpiperazin-1-yl)methyl]-1H -indole derivatives were synthesized, and their structures were confirmed by spectral analysis. All the compounds were tested for their cytotoxic activity in vitro against 3 human tumor cell lines: human liver (HUH7), breast (MCF7), and colon (HCT116). Among the designed derivatives, most of the compounds showed significant cytotoxicity against liver and colon cancer cell lines with lower IC50 concentrations than the standard drug 5-fluorouracil. Compound 3s, with 3,4-dichlorophenyl substituent on the piperazine ring, was the most active in suppressing the growth of all screened cancer cells. © TÜBITAK.

Course
Other identifiers
Book Title
Keywords
1,4-substituted piperazines, Anticancer activity, Cytotoxicity, Indole, Mannich base
Citation
Published Version (Please cite this version)