Sensing translocating polymers via induced magnetic fields

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buir.contributor.authorBüyükdağlı, Şahin
buir.contributor.orcidBüyükdağlı, Şahin|0000-0002-2133-470X
dc.citation.epage110en_US
dc.citation.issueNumber2
dc.citation.spage93
dc.citation.volumeNumber47
dc.contributor.authorBüyükdağlı, Şahin
dc.date.accessioned2024-03-14T13:29:53Z
dc.date.available2024-03-14T13:29:53Z
dc.date.issued2023
dc.departmentDepartment of Physics
dc.description.abstractThe requirement to boost the resolution of nanopore-based biosequencing devices necessitates the integration of novel biosensing techniques with reduced sensitivity to background noise. In this article, we probe the signatures of translocating polymers in magnetic fields induced by ionic currents through membrane nanopores. Within the framework of a previously introduced charge transport theory, we evaluate the magnetic field signals generated by voltage- and pressure-driven DNA translocation events in monovalent salt solutions. Our formalism reveals that in voltage-driven transport, the translocating polymer suppresses the induced magnetic field via the steric blockage of the ion current through the midpore. In the case of pressure-driven transport, the magnetic field reduction by translocation originates from the negative electrokinetic contribution of the anionic DNA surface charges to the streaming current predominantly composed of salt cations. The magnitude of the corresponding field signals is located in the nano-Tesla range covered by the resolution of the magnetoelectric sensors able to detect magnetic fields down to the pico-Tesla range. This suggests that the integration of magnetic field detection techniques into the current biosequencing approaches can complement efficiently the conventional biosensing strategies employing ionic current readouts with high susceptibility to background noise.
dc.description.provenanceMade available in DSpace on 2024-03-14T13:29:53Z (GMT). No. of bitstreams: 1 Sensing_translocating_polymers_via_induced_magnetic_fields.pdf: 3018637 bytes, checksum: ec7852e942d2c8368249ecf1914a0b1c (MD5) Previous issue date: 2023en
dc.identifier.doi10.55730/1300-0101.2739
dc.identifier.eissn1303-6122
dc.identifier.issn1300-0101
dc.identifier.urihttps://hdl.handle.net/11693/114759
dc.language.isoen
dc.publisherTÜBİTAK
dc.relation.isversionofhttps://dx.doi.org/10.55730/1300-0101.2739
dc.source.titleTurkish Journal of Physics
dc.subjectElectrostatics
dc.subjectHydrodynamics
dc.subjectPolymer translocation
dc.subjectIon transport
dc.subjectNanopores
dc.subjectMagnetic fields
dc.titleSensing translocating polymers via induced magnetic fields
dc.typeArticle

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