Browsing by Subject "Water solubility"

Now showing 1 - 3 of 3

Open Access
Antioxidant vitamin E/cyclodextrin inclusion complex electrospun nanofibers: enhanced water solubility, prolonged shelf life, and photostability of vitamin E
(American Chemical Society, 2017) Çelebioğlu, Aslı; Uyar, Tamer
Here, we demonstrated the electrospinning of polymer-free nanofibrous webs from inclusion complex (IC) between hydroxypropyl-β-cyclodextrin (HPβCD) and Vitamin E (Vitamin E/HPβCD-IC NF). The inclusion complexation between HPβCD and Vitamin E was prepared by using two different molar ratios (Vitamin E/HPβCD; 1:2 and 1:1), which correspond to theoretical value of ∼13% (w/w) and 26% (w/w) loading of Vitamin E in the nanofiber (NF) matrix. After electrospinning and storage, a very high loading of Vitamin E (up to ∼11% w/w, with respect to fiber matrix) was preserved in Vitamin E/HPβCD-IC NF. Because of the cyclodextrin inclusion complexation, only a minimal weight loss (only ∼2% w/w) was observed. While pure Vitamin E is insoluble in water, Vitamin E/HPβCD-IC NF web has displayed fast-dissolving behavior. Because of the greatly enhanced water-solubility of Vitamin E, Vitamin E/HPβCD-IC NF web has shown effective antioxidant activity. Additionally, Vitamin E/HPβCD-IC NF web has provided enhanced photostability for the sensitive Vitamin E by the inclusion complexation in which Vitamin E/HPβCD-IC NF still kept its antioxidant activity even after exposure to UV-light. Moreover, a 3 year-old Vitamin E/HPβCD-IC NF sample has shown very similar antioxidant efficiency when compared with freshly prepared Vitamin E/HPβCD-IC NF indicating that long-term stability was achieved for Vitamin E in the CD-IC fiber matrix. In brief, our results suggested that polymer-free electrospun Vitamin E/HPβCD-IC nanofibrous webs could have potential applications in food, pharmaceuticals, and healthcare thanks to its efficient antioxidant activity along with enhanced water-solubility, prolonged shelf life, and high photostability of Vitamin E.
Open Access
Electrospun nanofibers from cyclodextrin inclusion complexes with cineole and p-cymene: Enhanced water solubility and thermal stability
(Blackwell Publishing, 2018) Çelebioğlu, Aslı; Yıldız, Zehra İrem; Uyar, Tamer
The electrospinning of self-standing nanofibrous webs from inclusion complexes (IC) of cineole and p-cymene with two modified cyclodextrins (HPβCD, HPγCD) was achieved without using carrier polymeric matrix. Although they are highly volatile, certain amount of cineole and p-cymene was protected in cyclodextrin inclusion complexes nanofibers (CD-IC-NF). That is, 68.4%, 78.1%, 54.5% and 44.0% (w/w) of active agent were preserved in cineole/HPβCD-IC-NF, cineole/HPγCD-IC-NF, p-cymene/HPβCD-IC-NF and p-cymene/HPγCD-IC-NF, respectively. Remarkable, high thermal stability for cineole (~150 °C - 270 °C) and p-cymene (~150 °C - 275 °C) was achieved for CD-IC-NF samples due to CD-IC formation. The water solubility of cineole and p-cymene was significantly improved by inclusion complexation where CD-IC-NF samples become readily dissolved in water. In brief, essential oils and flavours such as cineole and p-cymene could be applicable in food and oral care applications owing to their fast-dissolving behaviour along with high water solubility, enhanced thermal stability and free-standing feature of CD-IC-NF webs.
Open Access
Molecular encapsulation of cinnamaldehyde within cyclodextrin inclusion complex electrospun nanofibers: fast-dissolution, enhanced water solubility, high temperature stability, and antibacterial activity of cinnamaldehyde
(American Chemical Society, 2019) Yıldız, Zehra İrem; Kılıç, Mehmet Emin; Durgun, Engin; Uyar, Tamer
The electrospinning of nanofibers (NFs) of cinnamaldehyde inclusion complexes (ICs) with two different hydroxypropylated cyclodextrins (CDs), hydroxypropyl-β-cyclodextrin (HP-β-CD) and hydroxypropyl-γ-cyclodextrin (HP-γ-CD), was successfully performed in order to produce cinnamaldehyde/CD-IC NFs without using an additional polymer matrix. The inclusion complexation between cinnamaldehyde and hydroxypropylated CDs was studied by computational molecular modeling, and the results suggested that HP-β-CD and HP-γ-CD can be inclusion complexed with cinnamaldehyde at 1:1 and 2:1 (cinnamaldehyde/CD) molar ratios. Additionally, molecular modeling and phase solubility studies showed that water solubility of cinnamaldehyde dramatically increases with cyclodextrin inclusion complex (CD-IC) formation. The HP-β-CD has shown slightly stronger binding with cinnamaldehyde when compared to HP-γ-CD for cinnamaldehyde/CD-IC. Although cinnamaldehyde is a highly volatile compound, it was effectively preserved with high loading by the cinnamaldehyde/CD-IC NFs. It was also observed that cinnamaldehyde has shown much higher temperature stability in cinnamaldehyde/CD-IC NFs compared to uncomplexed cinnamaldehyde because of the inclusion complexation state of cinnamaldehyde within the hydroxypropylated CD cavity. Moreover, cinnamaldehyde still has kept its antibacterial activity in cinnamaldehyde/CD-IC NF samples when tested against Escherichia coli. In addition, cinnamaldehyde/CD-IC NF mats were fast-dissolving in water, even though pure cinnamaldehyde has a water-insoluble nature. In brief, self-standing nanofibrous mats of electrospun cinnamaldehyde/CD-IC NFs are potentially applicable in food, oral-care, healthcare, and pharmaceutics because of their fast-dissolving character, enhanced water solubility, stability at elevated temperature, and promising antibacterial activity.