Browsing by Subject "Sulfonyl chloride"

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    Cytotoxic activities of some novel benzhydrylpiperazine derivatives
    (Georg Thieme Verlag, 2013) Gurdal, E. E.; Yarim, M.; Durmaz, I.; Cetin Atalay, R.
    This study presents the synthesis of nineteen 1-(substitutedbenzoyl)-4- benzhydrylpiperazine and 1-[(substitutedphenyl)sulfonyl]-4-benzhydrylpiperazine derivatives. In vitro cytotoxic activities of the compounds were screened against hepatocellular (HUH-7), breast (MCF-7) and colorectal (HCT-116) cancer cell lines by sulphorhodamine B assay. Among the test compounds, benzamide derivatives had high cytotoxic activity whereas sulfonamide derivatives showed variable 50% growth inhibition (GI50). © Georg Thieme Verlag KG Stuttgart · New York.