Browsing by Subject "Stress-induced-phosphoprotein 1"

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    Ant i-neuronal and stress-induced-phosphoprotein 1 antibodies in neuro-Behcet's disease
    (Elsevier, 2011-10-28) Vural, B.; Uğurel, E.; Tüzün, E.; Kürtüncü, M.; Zuliani, L.; Çavus, F.; İçoz, S.; Erdağ, E.; Gül, A.; Güre, A. O.; Vincent, A.; Özbek, U.; Eraksoy, M.; Demir, G. A.
    No disease-specific neuronal antibodies have so far been defined in neuro-Behçet's disease (NBD). Immunohistochemistry and immunocytochemistry studies showed antibodies to hippocampal and cerebellar molecular layers and the surface antigens of cultured hippocampal neurons in sera and/or cerebrospinal fluids (CSF) of 13 of 20 NBD and 6 of 20 BD patients but not in multiple sclerosis or headache controls. Screening with a protein macroarray led to identification of stress-induced-phosphoprotein-1 (STIP-1) as an antigenic target. High-titer STIP-1-antibodies were detected in 6 NBD patients' sera but not in controls. These results suggest that neuronal antibodies could be useful as diagnostic biomarkers in NBD. © 2011 Elsevier B.V.