Browsing by Subject "Recent researches"

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Open Access
Decomposing linear programs for parallel solution
(Springer, 1995-08) Pınar, Ali; Çatalyürek Ümit V.; Aykanat, Cevdet; Pınar, Mustafa
Coarse grain parallelism inherent in the solution of Linear Programming (LP) problems with block angular constraint matrices has been exploited in recent research works. However, these approaches suffer from unscalability and load imbalance since they exploit only the existing block angular structure of the LP constraint matrix. In this paper, we consider decomposing LP constraint matrices to obtain block angular structures with specified number of blocks for scalable parallelization. We propose hypergraph models to represent LP constraint matrices for decomposition. In these models, the decomposition problem reduces to the well-known hypergraph partitioning problem. A Kernighan-Lin based multiway hypergraph partitioning heuristic is implemented for experimenting with the performance of the proposed hypergraph models on the decomposition of the LP problems selected from NETLIB suite. Initial results are promising and justify further research on other hypergraph partitioning heuristics for decomposing large LP problems. © Springer-Verlag Berlin Heidelberg 1996.
Open Access
Evidence-Based Clinical Use of Nanoscale Extracellular Vesicles in Nanomedicine
(American Chemical Society, 2016-03) Fais, S.; O'Driscoll, L.; Borras, F. E.; Buzas, E.; Camussi, G.; Cappello, F.; Carvalho, J.; Cordeiro Da Silva, A.; Del Portillo, H.; El Andaloussi, S.; Ficko Trček, T.; Furlan, R.; Hendrix, A.; Gursel, I.; Kralj-Iglic, V.; Kaeffer, B.; Kosanovic, M.; Lekka, M. E.; Lipps, G.; Logozzi, M.; Marcilla, A.; Sammar, M.; Llorente, A.; Nazarenko, I.; Oliveira, C.; Pocsfalvi, G.; Rajendran, L.; Raposo, G.; Rohde, E.; Siljander, P.; Van, N. G.; Vasconcelos, M. H.; Yáñez-Mó, M.; Yliperttula, M. L.; Zarovni, N.; Zavec, A. B.; Giebel, B.
Recent research has demonstrated that all body fluids assessed contain substantial amounts of vesicles that range in size from 30 to 1000 nm and that are surrounded by phospholipid membranes containing different membrane microdomains such as lipid rafts and caveolae. The most prominent representatives of these so-called extracellular vesicles (EVs) are nanosized exosomes (70-150 nm), which are derivatives of the endosomal system, and microvesicles (100-1000 nm), which are produced by outward budding of the plasma membrane. Nanosized EVs are released by almost all cell types and mediate targeted intercellular communication under physiological and pathophysiological conditions. Containing cell-type-specific signatures, EVs have been proposed as biomarkers in a variety of diseases. Furthermore, according to their physical functions, EVs of selected cell types have been used as therapeutic agents in immune therapy, vaccination trials, regenerative medicine, and drug delivery. Undoubtedly, the rapidly emerging field of basic and applied EV research will significantly influence the biomedicinal landscape in the future. In this Perspective, we, a network of European scientists from clinical, academic, and industry settings collaborating through the H2020 European Cooperation in Science and Technology (COST) program European Network on Microvesicles and Exosomes in Health and Disease (ME-HAD), demonstrate the high potential of nanosized EVs for both diagnostic and therapeutic (i.e., theranostic) areas of nanomedicine.
Open Access
A survey on information security threats and solutions for Machine to Machine (M2M) communications
(Academic Press Inc., 2017) Tuna, G.; Kogias, D. G.; Gungor, V. C.; Gezer, C.; Taşkın, E.; Ayday, E.
Although Machine to Machine (M2M) networks allow the development of new promising applications, the restricted resources of machines and devices in the M2M networks bring several constraints including energy, bandwidth, storage, and computation. Such constraints pose several challenges in the design of M2M networks. Furthermore, some elements that contributed to the rise of M2M applications have caused several new security threats and risks, typically due to the advancements in technology, increasing computing power, declining hardware costs, and freely available software tools. Due to the restricted capabilities of M2M devices, most of the recent research efforts on M2M have focused on computing, resource management, sensing, congestion control and controlling technologies. However, there are few studies on security aspects and there is a need to introduce the threats existing in M2M systems and corresponding solutions. Accordingly, in this paper, after presenting an overview of potential M2M applications, we present a survey of security threats against M2M networks and solutions to prevent or reduce their impact. Then, we investigate security-related challenges and open research issues in M2M networks to provide an insight for future research opportunities. Moreover, we discuss the oneM2M standard, one of the prominent standard initiatives for more secure and smoother M2M networks and the Internet of Things. © 2017 Elsevier Inc.