Browsing by Subject "Photodynamic therapy (PDT)"

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    A bifunctional photosensitizer for enhanced fractional photodynamic therapy: singlet oxygen generation in the presence and absence of light
    (Wiley-VCH Verlag, 2016) Turan, I. S.; Yildiz, D.; Turksoy, A.; Gunaydin, G.; Akkaya, E. U.
    The photosensitized generation of singlet oxygen within tumor tissues during photodynamic therapy (PDT) is self-limiting, as the already low oxygen concentrations within tumors is further diminished during the process. In certain applications, to minimize photoinduced hypoxia the light is introduced intermittently (fractional PDT) to allow time for the replenishment of cellular oxygen. This condition extends the time required for effective therapy. Herein, we demonstrated that a photosensitizer with an additional 2-pyridone module for trapping singlet oxygen would be useful in fractional PDT. Thus, in the light cycle, the endoperoxide of 2-pyridone is generated along with singlet oxygen. In the dark cycle, the endoperoxide undergoes thermal cycloreversion to produce singlet oxygen, regenerating the 2-pyridone module. As a result, the photodynamic process can continue in the dark as well as in the light cycles. Cell-culture studies validated this working principle in vitro.
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    Synthesis and investigation of singlet oxygen production efficiency of photosensitizers based on meso-phenyl-2,5-thienylene linked porphyrin oligomers and polymers
    (Royal Society of Chemistry, 2015) Khan, R.; Idris, M.; Tuncel, D.
    Three new Zn(ii)-, oligo- and poly(2,5-thienylene)-linked porphyrins, bearing multiple triethylene glycol (TEG) groups, on all meso aryl positions were synthesized via Stille and Suzuki coupling reactions and their photophysical properties as well as singlet oxygen generation efficiencies have been investigated to elucidate the possibility of their use as a photosensitizer for photodynamic therapy (PDT) and photodynamic inactivation of bacteria. © The Royal Society of Chemistry 2015.
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    Tetrastyryl-BODIPY dyes as potential photosensitizers for photodynamic theraphy
    (2011) Yeşilgül, Nisa
    Photodynamic therapy (PDT) is a novel methodology for a wide range of treatments of cancerous and noncancerous diseases. Success of treatment and photodynamic action is highly dependent the performance of PDT agents. Therefore, PDT agents with unique photophysical properties are required in clinical applications. There are several photosensitizers in literature and some are available. However, most of them less than ideal due to limitations such as low molar absorptivity and photo stabilities. In this study, we synthesized near-IR tetrastyryl-Bodipy derivatives as photosensitizers. These sensitizers have strong absorption in therapeutic region and are good photo-generator of singlet oxygen. They are promising for photodynamic therapy with their favorable properties.