Browsing by Subject "Needle"

Filter results by typing the first few letters
Now showing 1 - 2 of 2
  • Thumbnail Image
    ItemOpen Access
    Development of bioactive peptide nanofibers for intervertebral disc regeneration
    (2017-08) Uysal, Özge
    Lower back pain (LBP) and neck problems are the most common orthopedic diseases worldwide, and the main reason behind LBP is intervertebral disc degeneration (IVDD). Therefore, specialized therapeutic applications to induce intervertebral disc (IVD) regeneration is a necessity. Here, we report the use of a collagen-mimetic bioactive peptide nanofiber scaffold (Col-PA/E-PA) for the improvement of disc regeneration by recapitulating the structure and function of the natural extracellular matrix (ECM) of intervertebral connective tissue. Following two weeks of degeneration, the bioactive nanofiber scaffold was topically applied and the IVD regeneration process was observed through histochemical analyses. The collagen-mimetic bioactive peptide nanofiber system was found to significantly promote glycosaminoglycan and collagen deposition at the site of injury compared to control nanofiber system and saline groups. In addition, the bioactive scaffold was consistently associated with lower values in degeneration scoring analyses, confirming the functional recovery of the tissue. Overall, the collagen-mimetic peptide nanofiber scaffold was able to prevent the progression of IVD degeneration and provide further functional recovery to the tissue.
  • Thumbnail Image
    ItemOpen Access
    System for MR image-guided prostate interventions: Canine study
    (Radiological Society of North America, Inc., 2003) Susil, R. C.; Krieger, A.; Derbyshire, J. A.; Tanacs, A.; Whitcomb, L. L.; Fichtinger, G.; Atalar, Ergin
    The purpose of this study was to demonstrate the use of a transrectal system that enables precise magnetic resonance (MR) image guidance and monitoring of prostate interventions. The system used a closed-bore 1.5-T MR imaging unit and enables one to take advantage of the higher signal-to-noise ratio achieved with traditional magnet designs, which is crucial for accurate targeting and monitoring of prostate interventions. In the first of the four canine studies, reliable needle placement, with all needles placed within 2 mm of the desired target site, was achieved. In two other studies, MR imaging was used to monitor distribution of injected contrast agent solution (gadopentetate dimeglumine mixed with trypan blue dye) in and around the prostate, thereby confirming that solution had been delivered to the desired tissue and also detecting faulty injections. In the final study, accurate placement and MR imaging of brachytherapy seeds in the prostate were demonstrated. The described system provides a flexible platform for a variety of minimally invasive MR image-guided therapeutic and diagnostic prostate interventions. © RSNA, 2003.