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Browsing by Subject "Nanopore"

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    Pulling a DNA molecule through a nanopore embedded in an anionic membrane: tension propagation coupled to electrostatics
    (Institute of Physics Publishing, 2020) Sarabadani, J.; Büyükdağlı, Şahin; Ala-Nissila, T.
    We consider the influence of electrostatic forces on driven translocation dynamics of a flexible polyelectrolyte being pulled through a nanopore by an external force on the head monomer. To this end, we augment the iso-flux tension propagation theory with electrostatics for a negatively charged biopolymer pulled through a nanopore embedded in a similarly charged anionic membrane. We show that in the realistic case of a single-stranded DNA molecule, dilute salt conditions characterized by weak charge screening, and a negatively charged membrane, the translocation dynamics is unexpectedly accelerated despite the presence of large repulsive electrostatic interactions between the polymer coil on the cis side and the charged membrane. This is due to the rapid release of the electrostatic potential energy of the coil during translocation, leading to an effectively attractive force that assists end-driven translocation. The speedup results in non-monotonic polymer length and membrane charge dependence of the exponent α characterizing the translocation time τ ∝ Nα 0 of the polymer with length N0. In the regime of long polymers N0 500, the translocation exponent exceeds its upper limit α = 2 previously observed for the same system without electrostatic interactions.

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