Browsing by Subject "Muscle"

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Open Access
Characterization of a novel zebrafish (Danio rerio) gene, wdr81, associated with cerebellar ataxia, mental retardation and dysequilibrium syndrome (CAMRQ)
(BioMed Central Ltd., 2015) Doldur-Balli, F.; Ozel, M. N.; Gulsuner, S.; Tekinay, A. B.; Ozcelik, T.; Konu, O.; Adams, M. M.
Background: WDR81 (WD repeat-containing protein 81) is associated with cerebellar ataxia, mental retardation and disequilibrium syndrome (CAMRQ2, [MIM 610185]). Human and mouse studies suggest that it might be a gene of importance during neurodevelopment. This study aimed at fully characterizing the structure of the wdr81 transcript, detecting the possible transcript variants and revealing its expression profile in zebrafish, a powerful model organism for studying development and disease. Results: As expected in human and mouse orthologous proteins, zebrafish wdr81 is predicted to possess a BEACH (Beige and Chediak-Higashi) domain, a major facilitator superfamily domain and WD40-repeats, which indicates a conserved function in these species. We observed that zebrafish wdr81 encodes one open reading frame while the transcript has one 5' untranslated region (UTR) and the prediction of the 3' UTR was mainly confirmed along with a detected insertion site in the embryo and adult brain. This insertion site was also found in testis, heart, liver, eye, tail and muscle, however, there was no amplicon in kidney, intestine and gills, which might be the result of possible alternative polyadenylation processes among tissues. The 5 and 18 hpf were critical timepoints of development regarding wdr81 expression. Furthermore, the signal of the RNA probe was stronger in the eye and brain at 18 and 48 hpf, then decreased at 72 hpf. Finally, expression of wdr81 was detected in the adult brain and eye tissues, including but not restricted to photoreceptors of the retina, presumptive Purkinje cells and some neurogenic brains regions. Conclusions: Taken together these data emphasize the importance of this gene during neurodevelopment and a possible role for neuronal proliferation. Our data provide a basis for further studies to fully understand the function of wdr81.
Open Access
Directionally selective fractional wavelet transform using a 2-d non-separable unbalanced lifting structure
(Springer, Berlin, Heidelberg, 2012) Keskin, Furkan; Çetin, A. Enis
In this paper, we extend the recently introduced concept of fractional wavelet transform to obtain directional subbands of an image. Fractional wavelet decomposition is based on two-channel unbalanced lifting structures whereby it is possible to decompose a given discrete-time signal x[n] sampled with period T into two sub-signals x 1[n] and x 2[n] whose average sampling periods are pT and qT, respectively. Fractions p and q are rational numbers satisfying the condition: 1/p+1/q=1. Filters used in the lifting structure are designed using the Lagrange interpolation formula. 2-d separable and non-separable extensions of the proposed fractional wavelet transform are developed. Using a non-separable unbalanced lifting structure, directional subimages for five different directions are obtained. © 2012 Springer-Verlag.
Open Access
Effects of various intervals applied in classical music on the ultrastructure of reflector nerve and muscle terminals (A musical, medical, biological and experimental study)
(2008) Mamedova L.; Metin I.; Ekici, N.; Huseyinov, M.; Huseyinova G.; Güner, S.S.
The aim of the study was to explore the effects of these intonations on the reflector nerve and muscle terminals of guinea pigs using electron microscopic approaches. Spazmatic shrinking of myocyte myofibrils together with degenerative changes in myocytes and nerve terminals occur with the application of strained intonations. Transmission function is also damaged related with this situation. Clear relaxative extensions in myocyte myofibrils and decrease in activity of nerve terminals were determined with the application of more extensive intonations. © 2008 Academic Journals Inc.
Open Access
Realistic rendering and animation of a multi-layered human body model
(IEEE, 2006) Yeşil, Mehmet Şahin; Güdükbay, Uğur
A framework for realistic rendering of a multi-layered human body model is proposed in this paper. The human model is composed of three layers: skeleton, muscle, and skin. The skeleton layer, represented by a set of joints and bones, controls the animation of the human body using inverse kinematics. Muscles are represented with action lines that are defined by a set of control points. An action line applies the force produced by a muscle on the bones and on the skin mesh. The skin layer is modeled as a 3D mesh and deformed during animation by binding the skin layer to both the skeleton and muscle layers. The skin is deformed by a two-step algorithm according to the current state of the skeleton and muscle layers. Performance experiments show that it is possible to obtain real-time frame rates for a moderately complex human model containing approximately 33,000 triangles on the skin layer. © 2006 IEEE.