Browsing by Subject "Mechanisms"

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    ItemOpen Access
    Feedforward and feedback processes in vision
    (Frontiers Research Foundation, 2015) Kafalıgönül, Hulusi; Breitmeyer, Buruno G.; Öğmen, Haluk
    [No abstract available]
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    ItemOpen Access
    Induction of ROS, p53, p21 in DEHP-and MEHP-exposed LNCaP cells-protection by selenium compunds
    (Elsevier, 2011-07) Erkekoglu, P.; Rachidi, W.; Yazgullu, O. G.; Giray, B.; Ozturk, M.; Favier, A.; Hincal, F.
    This study was designed to investigate the hypothesis that the toxic effects of di(2-ethylhexyl)phthalate (DEHP), the most abundantly used plasticizer and ubiquitous environmental contaminant that cause alterations in endocrine and spermatogenic functions in animals is mediated through the induction of reactive oxygen species (ROS) and activation of nuclear p53 and p21 proteins in LNCaP human prostate adenocarcinoma cell line. Protective effects of two selenocompounds, sodium selenite (SS) and selenomethionine (SM) were also examined. It was demonstrated that 24. h exposure of the cells to 3. mM DEHP or its main metabolite, mono(2-ethylhexyl)phthalate (MEHP, 3 μM) caused strongly amplified production of ROS. Both SS (30. nM) and SM (10 μM) supplementations reduced ROS production, and p53 and p21 activation that induced significantly only by MEHP-exposure. The overall results of this study indicated that the induction of oxidative stress is one of the important mechanisms underlying the toxicity of DEHP and this is mainly through the effects of the metabolite, MEHP. Generated data also emphasized the critical role of Se in modulation of intracellular redox status, implicating the importance of the appropriate Se status in cellular response against testicular toxicity of phthalates. © 2011 Elsevier Ltd.
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    ItemOpen Access
    Three-dimensional motion and dense-structure estimation using convex projections
    (SPIE, 1997-02) Alatan, A. Aydın; Erdem, A. Tanju; Onural, Levent
    We propose a novel method for estimating the 3D motion and dense structure of an object form its two 2D images. The proposed method is an iterative algorithm based on the theory of projections onto convex sets (POCS) that involves successive projections onto closed convex constraint sets. We seek a solution for the 3D motion and structure information that satisfies the following constraints: (i) rigid motion - the 3D motion parameters are the same for each point on the object. (ii) Smoothness of the structure - depth values of the neighboring points on the object vary smoothly. (iii) Temporal correspondence - the intensities in the given 2D images match under the 3D motion and structure parameters. We mathematically derive the projection operators onto these sets and discuss the convergence properties of successive projections. Experimental results show that the proposed method significantly improves the initial motion and structure estimates.