BUIR logo
Communities & Collections
All of BUIR
  • English
  • Türkçe
Log In
Please note that log in via username/password is only available to Repository staff.
Have you forgotten your password?
  1. Home
  2. Browse by Subject

Browsing by Subject "Lateral ventricles"

Filter results by typing the first few letters
Now showing 1 - 1 of 1
  • Results Per Page
  • Sort Options
  • Loading...
    Thumbnail Image
    ItemOpen Access
    MIR137 polygenic risk for schizophrenia and ephrin-regulated pathway: Role in lateral ventricles and corpus callosum volume
    (Asociacion Espanola de Psicologia Conductual, 2024-04-09) Blokland, G. A. M.; Maleki, N.; Jovicich, J.; Mesholam-Gately, R. I.; Delisi, L. E.; Turner, J. A.; Shenton, M. E.; Voineskos, A. N.; Kahn, R. S.; Roffman, J. L.; Holt, D. J.; Ehrlich, S.; Kikinis, Z.; Dazzan, P.; Murray, R. M.; Lee, J.; Sim, K.; Lam, M.; de Zwarte, S. M. C.; Walton, E.; Kelly, S.; Picchioni, M. M.; Bramon, E.; Makris, N.; David, A. S.; Mondelli, V.; Reinders, A. A. T. S.; Oykhman, E.; Morris, D. W.; Gill, M.; Corvin, A. P.; Cahn, W.; Ho, N.; Liu, J.; Gollub, R. L.; Manoach, D. S.; Calhoun, V. D.; Sponheim, S. R.; Buka, S. L.; Cherkerzian, S.; Thermenos, H. W.; Dickie, E. W.; Ciufolini, S.; Marques, T. Reis; Crossley, N. A.; Purcell, S. M.; Smoller, J. W.; Van Haren, N. E. M.; Toulopoulou, Timothea; Donohoe, G.; Goldstein, J. M.; Keshavan, M. S.; Petryshen, T. L.; del Re, E. C.
    Background/Objective. Enlarged lateral ventricle (LV) volume and decreased volume in the corpus callosum (CC) are hallmarks of schizophrenia (SZ). We previously showed an inverse correlation between LV and CC volumes in SZ, with global functioning decreasing with increased LV volume. This study investigates the relationship between LV volume, CC abnormalities, and the microRNA MIR137 and its regulated genes in SZ, because of MIR137 's essential role in neurodevelopment. Methods . Participants were 1224 SZ probands and 1466 unaffected controls from the GENUS Consortium. Brain MRI scans, genotype, and clinical data were harmonized across cohorts and employed in the analyses. Results. Increased LV volumes and decreased CC central, mid -anterior, and mid -posterior volumes were observed in SZ probands. The MIR137-regulated ephrin pathway was significantly associated with CC:LV ratio, explaining a significant proportion (3.42 %) of CC:LV variance, and more than for LV and CC separately. Other pathways explained variance in either CC or LV, but not both. CC:LV ratio was also positively correlated with Global Assessment of Functioning, supporting previous subsample findings. SNP -based heritability estimates were higher for CC central:LV ratio (0.79) compared to CC or LV separately. Discussion. Our results indicate that the CC:LV ratio is highly heritable, influenced in part by variation in the MIR137-regulated ephrin pathway. Findings suggest that the CC:LV ratio may be a risk indicator in SZ that correlates with global functioning.

About the University

  • Academics
  • Research
  • Library
  • Students
  • Stars
  • Moodle
  • WebMail

Using the Library

  • Collections overview
  • Borrow, renew, return
  • Connect from off campus
  • Interlibrary loan
  • Hours
  • Plan
  • Intranet (Staff Only)

Research Tools

  • EndNote
  • Grammarly
  • iThenticate
  • Mango Languages
  • Mendeley
  • Turnitin
  • Show more ..

Contact

  • Bilkent University
  • Main Campus Library
  • Phone: +90(312) 290-1298
  • Email: dspace@bilkent.edu.tr

Bilkent University Library © 2015-2025 BUIR

  • Privacy policy
  • Send Feedback