Browsing by Subject "Isothiocyanate"

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    Synthesis and cytotoxicity studies of novel benzhydrylpiperazine carboxamide and thioamide derivatives
    (Informa Healthcare, 2014) Gurdal, E. E.; Durmaz, I.; Cetin Atalay, R.; Yarim, M.
    Synthesis and cytotoxic activities of 32 benzhydrylpiperazine derivatives with carboxamide and thioamide moieties were reported. In vitro cytotoxic activities of compounds were screened against hepatocellular (HUH-7), breast (MCF-7) and colorectal (HCT-116) cancer cell lines by sulphorhodamine B assay. In general, 4-chlorobenzhydrylpiperazine derivatives were more cytotoxic than other compounds. In addition, thioamide derivatives (6a-g) have higher growth inhibition than their carboxamide analogs. © 2014 Informa UK Ltd. All rights reserved.