Browsing by Subject "Heart"
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Item Open Access Akut koroner sendromların otomatik ST/T sınıflandırıcısı ile erken tanısı(IEEE, 2014-10) Terzi, M. Begüm; Arıkan, Orhan; Abacı, A.; Candemir, M.; Dedoğlu, MehmetIn patients with acute coronary syndrome, temporary chest pains together with changes in ECG ST segment and T wave occur shortly before the start of myocardial infarction. In order to diagnose acute coronary syndromes early, a new technique which detects changes in ECG ST/T sections is developed. As a result of implementing the developed technique to real ECG recordings, it is shown that the proposed technique provides reliable detections. Therefore, the developed technique is expected to provide early diagnosis of acute coronary syndromes which will lead to a significant decrease in heart failure and mortality rates. © 2014 IEEE.Item Open Access Characterization of a novel zebrafish (Danio rerio) gene, wdr81, associated with cerebellar ataxia, mental retardation and dysequilibrium syndrome (CAMRQ)(BioMed Central Ltd., 2015) Doldur-Balli, F.; Ozel, M. N.; Gulsuner, S.; Tekinay, A. B.; Ozcelik, T.; Konu, O.; Adams, M. M.Background: WDR81 (WD repeat-containing protein 81) is associated with cerebellar ataxia, mental retardation and disequilibrium syndrome (CAMRQ2, [MIM 610185]). Human and mouse studies suggest that it might be a gene of importance during neurodevelopment. This study aimed at fully characterizing the structure of the wdr81 transcript, detecting the possible transcript variants and revealing its expression profile in zebrafish, a powerful model organism for studying development and disease. Results: As expected in human and mouse orthologous proteins, zebrafish wdr81 is predicted to possess a BEACH (Beige and Chediak-Higashi) domain, a major facilitator superfamily domain and WD40-repeats, which indicates a conserved function in these species. We observed that zebrafish wdr81 encodes one open reading frame while the transcript has one 5' untranslated region (UTR) and the prediction of the 3' UTR was mainly confirmed along with a detected insertion site in the embryo and adult brain. This insertion site was also found in testis, heart, liver, eye, tail and muscle, however, there was no amplicon in kidney, intestine and gills, which might be the result of possible alternative polyadenylation processes among tissues. The 5 and 18 hpf were critical timepoints of development regarding wdr81 expression. Furthermore, the signal of the RNA probe was stronger in the eye and brain at 18 and 48 hpf, then decreased at 72 hpf. Finally, expression of wdr81 was detected in the adult brain and eye tissues, including but not restricted to photoreceptors of the retina, presumptive Purkinje cells and some neurogenic brains regions. Conclusions: Taken together these data emphasize the importance of this gene during neurodevelopment and a possible role for neuronal proliferation. Our data provide a basis for further studies to fully understand the function of wdr81.Item Open Access Proof-of-concept energy-efficient and real-time hemodynamic feature extraction from bioimpedance signals using a mixed-signal field programmable analog array(IEEE, 2017) Töreyin, Hakan; Shah, S.; Hersek, S.; İnan, O. T.; Hasler, J.We present a mixed-signal system for extracting hemodynamic parameters in real-time from noisy electrical bioimpedance (EBI) measurements in an energy-efficient manner. The proof-of-concept system consists of floating-gate-based analog signal processing (ASP) electronics implemented on a field programmable analog array (FPAA) chip interfaced with an on-chip low-power microcontroller. Physiological features important for calculating hemodynamic parameters (e.g., heart rate, blood volume, and blood flow) are extracted using the custom signal processing circuitry, which consumes a total power of 209 nW. Testing of the signal processing circuitry has been performed using ∼580 sec of an impedance plethysmography dataset collected from the knee of a subject using a custom analog EBI front-end. Results show the similarities of variations in heart rate, blood volume, and blood flow calculated using features extracted by the ASP circuitry implemented on an FPAA and a MATLAB digital signal processing algorithm.Item Open Access Terfenadin, Setirizin, Loratadin ve Akrivastinin kalp üzerine olan etkilerinin değerlendirilmesi(Galenos Yayinevi, 1997) Erel, A.; Oztas, M. O.; Alkan, M.; Ilter, N.; Gurer, M. A.Design. - Non-sedative antihistanimic drugs, terfenadine, cetinizine, loratadine and acrivastine were given to four groups of patients each consisted of 10 patients for 10 days. Blood chemistry and daily electrocardrographic changes were followed. Conclusion. - Non-sedative antihistaminics have no cardiac side effects as they are given alone, in conventional treatment dose.