Browsing by Subject "Glycopeptides"

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    Biomedical applications of peptide nanostructures
    (2016-04) Şardan Ekiz, Melis
    Thesis (Ph. D.): Bilkent University, Materials Science and Nanotechnology Program, İhsan Doğramacı Bilkent University, 2016.
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    Spatial organization of functional groups on bioactive supramolecular glycopeptide nanofibers for differentiation of mesenchymal stem cells (MSCs) to brown adipogenesis
    (American Chemical Society, 2016-12) Caliskan, O. S.; Sardan, Ekiz M.; Tekinay, A. B.; Güler, Mustafa O.
    Spatial organization of bioactive moieties in biological materials has significant impact on the function and efficiency of these systems. Here, we demonstrate the effect of spatial organization of functional groups including carboxylate, amine, and glucose functionalities by using self-assembled peptide amphiphile (PA) nanofibers as a bioactive scaffold. We show that presentation of bioactive groups on glycopeptide nanofibers affects mesenchymal stem cells (MSCs) in a distinct manner by means of adhesion, proliferation, and differentiation. Strikingly, when the glutamic acid is present in the glycopeptide backbone, the PA nanofibers specifically induced differentiation of MSCs into brown adipocytes in the absence of any differentiation medium as shown by lipid droplet accumulation and adipogenic gene marker expression analyses. This effect was not evident in the other glycopeptide nanofibers, which displayed the same functional groups but with different spatial organization. Brown adipocytes are attractive targets for obesity treatment and are found in trace amounts in adults, which also makes this specific glycopeptide nanofiber system an attractive tool to study molecular pathways of brown adipocyte formation.
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    Transition metals for the synthesis of glycopolymers and glycopolypeptides
    (Wiley-VCH Verlag, 2015) Islam, M.; Shaikh, A. Y.; Hotha, S.
    Glycopolymers and glycopolypeptides are an important class of molecules, which can self-assemble to various interesting biohybrid materials. It is envisaged that the glycans impart good immunological response, and the aliphatic or polypeptide backbone can give tertiary structure for the resulting glycopolymers. The major bottleneck in the synthesis of glycopolymers or glycopolypeptides is the access to suitable building blocks and polymerization methods. This review describes methods that have recently been explored for the successful synthesis of many useful glycomonomers that could be polymerized to afford glycopolymers and/or glycopolypeptides.