Browsing by Subject "Geographic distribution"
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Item Open Access Dating the sea of Marmara sediments by a uniform mixing model(Elsevier, 1996) Gökmen, A.; Yıldız, M.; Erten, H. N.; Salihoğlu, İ.The sedimentation rates and ‘t”Pb fluxes on sediment surfaces were measured in the north, northwestern and southwestern parts of the Sea of Marmara. Each core had varying thickness of constant 2’0Pb activity regions followed by a decreasing part with sediment depth. The sedimentation rates of the samples collected from the Bosporus and the Dardanelles could not be analysed due to the homogenization of activity in the strong currents of these straits. A untform mixing model is proposed for the simultaneous analysis of sedimentation rates, “‘Pb fluxes and mixing depths from the experimental data. In this model, the parameters were obtained by minimizing the multi-dimensional parameter space using a grid search algorithm. The 2’0Pbfluxes were found to be about 0.048 Bqcm-’ year-t for all sampling sites. The mass sedimentation rates were 0.19 and 0.073gcm-2 year-’ at the shelves of the Bosporus and the Dardanelles and 0.055 and 0.064 g cm-’ year -’ in the northwestern and middle northern basins, respectively, of the Sea of Marmara.Item Open Access Frequent demonstration of human herpesvirus 8 (HHV-8) in bone marrow biopsy samples from Turkish patients with multiple myeloma (MM)(Nature Publishing, 2001) Beksac, M.; Ma, M.; Akyerli, C.; DerDanielian, M.; Zhang, L.; Liu, J.; Arat, M.; Konuk, N.; Koc, H.; Ozcelik, T.; Vescio, R.; Berenson, J. R.In order to investigate the frequency of HHV-8 in MM patients from another geographic location, we obtained fresh bone marrow (BM) biopsies from Turkish patients with MM (n = 21), monoclonal gammopathy of undetermined significance (MGUS) (n = 2), plasmacytoma (n = 1) with BM plasma cell infiltration, various hematological disorders (n = 6), and five healthy Turkish controls. The frequency of HHV-8 was analyzed by polymerase chain reaction (PCR) in two independent laboratories in the USA and in Turkey. Using fresh BM biopsies, 17/21 MM patients were positive for HHV-8 whereas all five healthy controls, and six patients with other hematological disorders were negative. Two patients with MGUS, and one patient with a solitary plasmacytoma were also negative. The data from the two laboratories were completely concordant. Also using primer pairs for v IRF and v IL-8R confirmed the results observed with the KS330233 primers. Furthermore, sequence analysis demonstrated a C3 strain pattern in the ORF26 region which was also found in MM patients from the US. Thus, HHV-8 is present in the majority of Turkish MM patients, and the absence of the virus in healthy controls further supports its role in the pathogenesis of MM.