Browsing by Subject "Genetic engineering"
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Item Open Access Biosystems engineering of prokaryotes with tumor-killing capacities(Bentham Science Publishers Ltd., 2016) Kalyoncu, E.; Olmez, T. T.; Ozkan, A. D.; Sarioglu, O. F.Certain bacteria selectively attack tumor tissues and trigger tumor shrinkage by producing toxins and modulating the local immune system, but their clinical utility is limited because of the dangers posed by systemic infection. Genetic engineering can be used to minimize the risks associated with tumor-targeting pathogens, as well as to increase their efficiency in killing tumor cells. Advances in genetic circuit design have led to the development of bacterial strains with enhanced tumor-targeting capacities and the ability to secrete therapeutics, cytotoxic proteins and prodrug-cleaving enzymes, which allows their safe and effective use for cancer treatment. The present review details the recent advances in the design and application of these modified bacterial strains.Item Open Access High school biology teachers and bioethics: awareness, attitudes and teaching practices(2021-01) Deniz, ÖzgeNowadays, with the advancement of technology, biotechnology and genetic engineering applications have gained momentum, especially in the field of medicine, very important developments have been made. However, the risks and ethical aspects of these practices cause conflict among scientists. These applications within the scope of bioethics are taught within the high school MoNE curriculum and the IBDP curriculum. Disagreements between scientists are likely to manifest themselves in biology classes. This study investigates the bioethics awareness of high school biology teachers, their attitudes towards bioethics and teaching these subjects, and their instructional strategies. Thus, the research aims to contribute to bioethics education. In this study, the mixed method in which qualitative and quantitative research approaches are applied together was used. The data of the study were analysed by descriptive statistics and content analysis methods. Analysis results determined that teachers have bioethical awareness, have a positive attitude towards bioethics, and make use of various teaching strategies that they think are effective for teaching.Item Open Access Multi-material specific, targeted self-assembly of nanocrystal emitters using genetically engineered peptides on optoelectronic microchips(IEEE, 2008-11) Zengin, Güliş; Şeker, U. O. S.; Koç, Aslı; Mutlugün, Evren; Akyüz, Özgün; Sarı, Emre; Sarıkaya, M.; Tamerler, C.; Demir, Hilmi VolkanWe demonstrated material-specific binding of the quantum dot emitters hybridized with GEPI on multi-material patterned microchips. These proof-of-concept results open up new opportunities in nanophotonics, allowing for more specific and controlled assembly of quantum dots in optoelectronic devices and building of novel molecular organic-inorganic hybrid devices