Browsing by Subject "Frequency analysis"
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Item Open Access Frequent demonstration of human herpesvirus 8 (HHV-8) in bone marrow biopsy samples from Turkish patients with multiple myeloma (MM)(Nature Publishing, 2001) Beksac, M.; Ma, M.; Akyerli, C.; DerDanielian, M.; Zhang, L.; Liu, J.; Arat, M.; Konuk, N.; Koc, H.; Ozcelik, T.; Vescio, R.; Berenson, J. R.In order to investigate the frequency of HHV-8 in MM patients from another geographic location, we obtained fresh bone marrow (BM) biopsies from Turkish patients with MM (n = 21), monoclonal gammopathy of undetermined significance (MGUS) (n = 2), plasmacytoma (n = 1) with BM plasma cell infiltration, various hematological disorders (n = 6), and five healthy Turkish controls. The frequency of HHV-8 was analyzed by polymerase chain reaction (PCR) in two independent laboratories in the USA and in Turkey. Using fresh BM biopsies, 17/21 MM patients were positive for HHV-8 whereas all five healthy controls, and six patients with other hematological disorders were negative. Two patients with MGUS, and one patient with a solitary plasmacytoma were also negative. The data from the two laboratories were completely concordant. Also using primer pairs for v IRF and v IL-8R confirmed the results observed with the KS330233 primers. Furthermore, sequence analysis demonstrated a C3 strain pattern in the ORF26 region which was also found in MM patients from the US. Thus, HHV-8 is present in the majority of Turkish MM patients, and the absence of the virus in healthy controls further supports its role in the pathogenesis of MM.Item Open Access Left-and right-handed transmission peaks near the magnetic resonance frequency in composite metamaterials(American Physical Society, 2004) Katsarakis, N.; Koschny, T.; Kafesaki, M.; Economou, E. N.; Özbay, Ekmel; Soukoulis, C. M.We present free-space microwave measurements on composite metamaterials (CMMs) consisting of split ring resonators (SRRs) and wires either on the same dielectric board or on alternating boards. Our experimental results disprove the widely held belief that the occurrence of a CMM transmission peak within the stop bands of the SRRs alone and wires alone constitutes a clear demonstration of left-handed (LH) behavior. This belief is based on the assumption that the stop bands of SRRs alone and wires alone are not affected by the simultaneous presence of both. We show here that this assumption is wrong: The effective plasma frequency, ω′p, of the CMM is actually substantially lower than the wires-only plasma frequency, ωp; furthermore, the in-plane wires, as opposed to the off-plane case, push the magnetic resonance frequency of the SRRs, ωm, to a higher value, ω′m, for the CMM. We conclude that the criterion for deciding whether a peak in the transmission spectrum through a CMM is really left-handed is for the peak to be located above ω′m and below ω′p. Our results provide a definite way for experimentally identifying ω′p.