Browsing by Subject "Digital circuits"

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Open Access
Cellular biosensors with engineered genetic circuits
(American Chemical Society, 2018) Saltepe, Behide; Kehribar, Ebru Şahin; Yirmibeşoǧlu, Side Selin Su; Şeker, Urartu Özgür Şafak
An increasing interest in building novel biological devices with designed cellular functionalities has triggered the search of innovative tools for biocomputation. Utilizing the tools of synthetic biology, numerous genetic circuits have been implemented such as engineered logic operation in analog and digital circuits. Whole cell biosensors are widely used biological devices that employ several biocomputation tools to program cells for desired functions. Up to the present date, a wide range of whole-cell biosensors have been designed and implemented for disease theranostics, biomedical applications, and environmental monitoring. In this review, we investigated the recent developments in biocomputation tools such as analog, digital, and mix circuits, logic gates, switches, and state machines. Additionally, we stated the novel applications of biological devices with computing functionalities for diagnosis and therapy of various diseases such as infections, cancer, or metabolic diseases, as well as the detection of environmental pollutants such as heavy metals or organic toxic compounds. Current whole-cell biosensors are innovative alternatives to classical biosensors; however, there is still a need to advance decision making capabilities by developing novel biocomputing devices.
Open Access
A Wired-AND Current-Mode Logic Circuit Technique in CMOS for Low-Voltage, High-Speed and Mixed-Signal VLSIC
(1997) Ungan I.E.; Aşkar, M.
A wired-AND current-mode logic (WCML) circuit technique in CMOS technology for low-voltage and high-speed VLSI circuits is proposed, and a WCML cell library is developed using standard 0.8 micron CMOS process. The proposed WCML technique applies the analog circuit design methodologies to the digital circuit design. The input and output logic signals are represented by current quantities. The supply current of the logic circuit is adjustable for the required logic speed and the switching noise level. The noise is reduced on the power supply lines and in the substrate by the current-steering technique and by the smooth swing of the reduced node potentials. Precise analog circuits and fast digital circuits can be integrated on the same silicon substrate by using the low noise property of the WCML. It is shown by the simulations that at low supply voltages, the WCML is faster and generates less switching noise when compared to the static-CMOS logic. At high speeds, the power dissipation of the WCML is less than that of the static-CMOS logic.