Browsing by Subject "Children"

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1980-2017 yılları arasında Atatürk çocuk yuvası
(Bilkent University, 2019) Seçilmiş, Dicle; Karakaş, Feyza; Kılıç, Gamze Nur; Arık, Zeynep Güşta; Karvan, Zeynep
Bu çalışma 1925’te Keçiören'de kurulan kimsesiz ve bakıma muhtaç çocuklara yıllarca ev sahipliği yapan Atatürk Çocuk Yuvası tarihine ışık tutmaktadır. Bu araştırmada kurumun yapılanma sistemi, çocuklarla olan iletişim gibi temel konular ele alınmaktadır. Atatürk Çocuk Yuvası Türkiye Cumhuriyeti tarihindeki en eski kurumlardan biri olup ailesi olmayan çocuklara yuva olma misyonuyla kurulmuştur. Kuruluşundan bu yana binlerce çocuğun psikolojik ve fizyolojik gelişimiyle ilgilenen yuva, değişen hükümetlerle birlikte yeniden düzenlenmiştir. Yönetime geçen her hükümet yuvayı çocuklar için daha iyi bir yer haline getirmeye çabalamış ve yurdun “Sevgi Evleri” projesi uygulanmaya başlanana kadar yuva misyonunu korumuştur. Yurt sistemi yerine gelen ve çocukların 5-6 kişilik evlere dağıtıldığı sevgi evi projesiyle birlikte Atatürk Çocuk Yuvası’nın fonksiyonu değişmiştir. Problemli çocuklar, istismara uğrayan, bağımlı çocuklara ev sahipliği yapmaya başlayan ve onlara özel bakım sağlayan Atatürk Çocuk Yuvası, 2017’den bu yana görevini bu şekilde devam ettirmektedir.
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27 Mayıs Darbesi ve takibindeki süreçte çocuk olmak
(Bilkent University, 2020) Sayran, Deniz; Gönen, Zeynep; Güney, Çağla; İnce, Leyal; Kol, Cemre
İhsan Doğramacı Bilkent Üniversitesi’nin HIST 200 dersi için yapılan bu çalışmasında 27 Mayıs 1960 darbesinin çocukluk ve gençlik çağındaki bireyler üzerindeki etkisi araştırılmıştır.
Open Access
An infant with zoonotic pulmonary tuberculosis due to mycobacterium bovis
(2023-04-12) Üstündaǧ, G.; Şahin, A.; Yazıcı, Yücehan Yılmaz; Aksay, A.; Biçmen, C.; Belkaya, Serkan; Yilmaz, D.
Bovine tuberculosis might be seen in low-income countries, especially in children fed with raw milk. The most common transmission route is fecal-oral way, and it is most likely through unpasteurized dairy products. Although clinical and radiological findings are like non-zoonotic tuberculosis, treatment approaches may differ in individuals with zoonotic tuberculosis. Prevention of zoonotic diseases requires multidisciplinary approaches. These approaches include the development of veterinary and surveillance studies for the detection of communicable diseases in farm animals, as well as informing the public about raw milk consumption. In this case report, a patient with zoonotic pulmonary tuberculosis related to Mycobacterium bovis because of consumption of raw milk was presented. A five-month-old male was admitted to the hospital due to a persistent, feverless, non-productive cough since birth. Empirical antibiotic treatment was started with a preliminary diagnosis of pneumonia because of left upper lobe and right pericardial infiltration on chest X-ray. However, after two weeks of antimicrobial therapy, the patient's clinical and laboratory findings did not improve. This led to the referral for a computed tomography imaging, which revealed tracheomalacia, consolidation on the right upper lobe, an indistinguishable mass or consolidation on the left middle lobe of the lung, peribronchial thickening on the basal segment of the lower lobe, and mediastinal lymphadenopathy. Three consecutive days of fasting gastric lavage fluid was sent to the reference laboratory for acid-resistant bacillus examination, polymerase chain reaction (PCR) and culture studies. As the clinical findings were compatible and PCR was positive, the patient was started on quadruple antituberculous therapy. After initiation of anti-tuberculosis drugs, the patient's findings radiologically and clinically were improved. Mycobacterium bovis was grown in the culture. In the meantime, it was discovered that the patient was fed with raw milk. Due to the patient's clinical symptoms and the growth of Mycobacterium bovis in the gastric lavage fluid culture, the diagnosis of bovine tuberculosis was made. The culprit was that the milk of the cow belonging to the patient's family, which was later found to be infected with M.bovis, was milked and given to the patient without boiling. Today, unpasteurized dairy products continue to be consumed, especially in rural areas. One of the most important steps to prevent zoonotic diseases is to raise awareness about not consuming raw milk and undercooked meat. To elucidate the epidemiological link in childhood, taking a good anamnesis, including questioning raw milk consumption, is essential in the diagnosis of tuberculosis. © 2023 Ankara Microbiology Society. All rights reserved.
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Aytül Akal; çağdaş çocuk yazınımızda bir kilometre taşı
(2000) Göknil, Can
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Bir nesli uyutarak büyüten efsane: çocuk programı "Uykudan önce"
(Bilkent University, 2018) Erseven, İdil Türküsu; Tok, Fatmanur; Pöç, Ece; Keleşoğlu, Sena; Dilmen, Merve
Televizyonun 1940’lı yıllarda insan hayatında yer almaya başlamasıyla birlikte, bütün dünyada izleyiciye çeşitli programlar sunulmuştur. Bu programların içinde çocuk programlarının ayrı bir yeri vardır. Türkiye’de yayınlanan ilk çocuk programlarından olan Uykudan önce, türünün en önemli temsilcilerindendir. Bu programın çocuklar üzerinde olumlu etkileri vardır; bunlardan biri, çocukların kendilerini birer birey olarak hissetmeleridir. Bunun nedeni, programda çocuklarla sohbet tarzında konuşmaların olmasıdır. Programda kullanılan anlatım tekniklerinin çeşitliliği de çocukların ilgisini taze tutmuştur. Uykudan önce’nin ilk sunucuları Ergün Uçucu ve Adile Naşit, programın izlenmesinde büyük rol oynamışlardır. 1980’li yıllarda başlayan program, çeşitli sunucularla uzun yıllar devam etmiştir. Ayrıca, verilen öğütlerle çocukların uyku düzenleri sağlanmış, günlük hayatlarının planlanmasına yardımcı olunmuştur. Programın izlenme nedenleri arasında, anlatılan masallar, çizgi filmler ve verilen öğütler yer almaktadır. Bu araştırmada Uykudan önce programının yayınlandığı 1980’li yıllarda TRT çocuk ve Gençlik Programları Bölümü Müdürlüğü yapmış olan Tekin özertem, TRT Baş kameramanlarından Sinan Aydoğan, yapımcı ve yönetmenlerinden Nur İdil Büyükcivelek, teknik yönetmenlerinden Nusrettin Aslan, kameraman ve eğitimci Fuat Ovat’ın program hakkındaki bilgilerine başvurulmuştur.
Open Access
Characterization of functional and molecular properties of circulating extracellular vesicles of childhood idiopathic nephrotic syndrome patients
(2021-10) Eroğlu, Fehime Kara
Nephrotic syndrome (NS) is one of the most common causes of glomerular disease in children and is characterized by the triad of proteinuria, hypoalbuminemia, and edema. The major molecular event in the pathogenesis of NS is the disruption of the glomerular filtration barrier, which is primarily driven by podocyte injury. The most common clinical presentation of NS in children is steroid-sensitive nephrotic syndrome (SSNS), characterized by complete remission within 4 weeks of steroid therapy and no apparent glomerular change in the light microscopic evaluation of kidney biopsies, thereby named as Minimal Change Disease (MCD). Since previous research suggests a role of a circulating factor in the pathogenesis of steroid-sensitive nephrotic syndrome (SSNS), we speculated that circulating plasma extracellular vesicles (EVs) are a candidate source of such a soluble mediator. Here, we aimed to characterize and try to delineate the effects of these EVs in vitro. Plasma EVs from 20 children with SSNS in relapse and remission, 10 healthy controls and 6 disease controls were obtained by serial ultracentrifugation. Characterization of these EVs was performed by electron microscopy, flow cytometry and western blotting. The major proteins from the plasma EVs were identified via mass spectrometry. A Gene Ontology classification analysis and ingenuity pathway analysis were performed on selectively expressed EV proteins during relapse. Immortalized human podocyte culture was used to detect the effects of EVs on podocytes. The protein content and the particle number of plasma EVs were significantly increased during NS relapse. Relapse NS EVs selectively express proteins which involved actin cytoskeleton rearrangement. Among these, the level of RAC-GTP was significantly increased in relapse EVs compared to remission and disease control EVs. Relapse EVs were efficiently internalized by podocytes and induced significantly enhanced motility and albumin permeability. Moreover, relapse EVs induced significantly higher levels of RAC-GTP and phospho p38 (p-p38) and decreased levels of synaptopodin in podocytes. Circulating relapse EVs are biologically active molecules that carry active RAC1 as cargo and induce recapitulation of the nephrotic syndrome phenotype in podocytes in vitro.
Open Access
Children's mobile communicative practices and locational privacy
(Oxford University Press, 2022-09-01) Özkul, Didem
Children start using smartphones increasingly from early ages. This makes it more difficult for them to develop an understanding of online privacy and managing their personal data. Many parents monitor and regulate children's online media use. However, they also encourage using smartphones to ensure the safety and security of their children. This study explores how children use smartphones in relation to their understanding of privacy of communication, content, data, and location. It examines data from 7 focus groups with arts-based methods conducted with 37 children in UK. The findings suggest that children think of their smartphones as a private communication technology and a private place, and they manage their locational privacy based on the necessity of using a mobile app and through adjusting the location settings on their phones. The findings also suggest that privacy of mobile data and user content are dependent on where mobile communication takes place. © 2022 The Author(s). Published by Oxford University Press on behalf of International Communication Association.
Open Access
Circulating extracellular vesicles of patients with steroid-sensitive nephrotic syndrome have higher RAC1 and induce recapitulation of nephrotic syndrome phenotype in podocytes
(American Physiological Society, 2021-11-09) Kara Eroğlu, Fehime; Yazar, Volkan; Guler, Ulku; Yıldırım, Muzaffer; Yıldırım, Tuğçe; Gungor, Tulin; Celikkaya, Evra; Karakaya, Deniz; Turay, Nilsu; Ciftci Dede, Eda; Korkusuz, Petek; Salih, Bekir; Bulbul, Mehmet; Gürsel, İhsan
Since previous research suggests a role of a circulating factor in the pathogenesis of steroid-sensitive nephrotic syndrome (NS), we speculated that circulating plasma extracellular vesicles (EVs) are a candidate source of such a soluble mediator. Here, we aimed to characterize and try to delineate the effects of these EVs in vitro. Plasma EVs from 20 children with steroid-sensitive NS in relapse and remission, 10 healthy controls, and 6 disease controls were obtained by serial ultracentrifugation. Characterization of these EVs was performed by electron microscopy, flow cytometry, and Western blot analysis. Major proteins from plasma EVs were identified via mass spectrometry. Gene Ontology classification analysis and Ingenuity Pathway Analysis were performed on selectively expressed EV proteins during relapse. Immortalized human podocyte culture was used to detect the effects of EVs on podocytes. The protein content and particle number of plasma EVs were significantly increased during NS relapse. Relapse NS EVs selectively expressed proteins that involved actin cytoskeleton rearrangement. Among these, the level of RAC-GTP was significantly increased in relapse EVs compared with remission and disease control EVs. Relapse EVs were efficiently internalized by podocytes and induced significantly enhanced motility and albumin permeability. Moreover, relapse EVs induced significantly higher levels of RAC-GTP and phospho-p38 and decreased the levels of synaptopodin in podocytes. Circulating relapse EVs are biologically active molecules that carry active RAC1 as cargo and induce recapitulation of the NS phenotype in podocytes in vitro.
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Çocuk yazını ve "Kardelen"
(1999) Aslankara, M. Sadık
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Çocuklar nasıl bıçaklanır (?)
(1984) Özturanlı, Ö. İskender
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Çocuklar öldürülmesin: Ölü çocuk koleksiyoncularına, zorbalara karşı tepki, yine onların en çok korktukları çocuklardan geldi
(1992) Akın, Sunay
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Çocuklar üzerine Muzaffer İzgü ile söyleşi
(1995) Şeyhoğlu, Recai
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Çocukluğun düşsel uçurtmaları
(1998) Günel, Burhan
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Dünyayı dolduran kiraz
(1990)
Open Access
The effect of chromatic and achromatic color schemes on children’s emotions in a preschool classroom
(2016-05) Dalirnaghdeh, Donya
Color is salient design element that can influence people's behaviours and emotions in the interior space, it can also trigger specific physical and psychological responses in human beings. Therefore, its proper use in the interior space can lead to positive outcomes such as creating a healthier environment. In that regard, this research examines the effect of chromatic and achromatic color schemes on color-emotion associations in children in the interior space of a general classroom. The goal of this study is determining whether the responses caused by color are strong enough to create a positive or negative emotion in a child. Furthermore, saturation maybe more effective than hue in determining whether a color is calming or exciting, in addition, children prefer brighter and more saturated colors to less saturated ones. In that sense, high and low saturated blue, high and low saturated red as chromatic colors and high and low saturated grey and white were selected as achromatic colors. This study was conducted on eighty preschool children with 5 years of age, from two private preschools in Ankara, Turkey. Photographic simulations were used as the tool to create different views of the classrooms and the children were asked to match each view to one facial expression representing anger, sadness, neutral and happiness. The results indicated that classrooms with high saturated blue, low saturated red and white as the wall colors elicited positive emotions in the child while the rest were associated with either negative emotions or no emotions at all.
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Eğitimimiz ve kitaplar
(1985)
Open Access
Ethnic identity and discrimination among children
(Elsevier BV, 2012-12) Friesen, J.; Arifovic, J.; Wright, S. C.; Ludwig, A.; Giamo, L.; Baray, G.
We engaged over 430 Canadian children in a series of activities designed to reveal their evaluations of three ethnic groups (White, East Asian and South Asian), their identification with these groups, and their behavior towards them in a dictator game. Our experiments took place at the children’s schools during their normal school day, allowing us to evaluate the salience and effects of ethnic identities on economically relevant behavior in an important natural setting. We find that children from the dominant White category have a clear sense of White ethnic identity, and tend to favor White recipients in the dictator game relative to East Asian or South Asian recipients. Minority East Asian children reveal a more complex ethnic identity; they perceive themselves to be equally similar to White and East Asian children. Unlike Whites, East Asian children do not favor recipients from their own East Asian category, nor do they favor recipients with whom they tend to identify. If anything, East Asian children show out-group favoritism.
Open Access
Evaluation of cortical thickness and brain volume on 3 Tesla magnetic resonance imaging in children with frontal lobe epilepsy
(Springer, 2020) Kural-Rahatlı, F.; Sezer, T.; Has, Arzu Ceylan; Ağıldere, A. M.
Background Frontal lobe epilepsy (FLE) is the most common epilepsy syndrome in the pediatric population; however, brain magnetic resonance imaging (MRI) of the children with FLE is frequently normal. We use both cortical thickness and brain volume measurements to report on cortical changes in children with FLE. Our aim was to determine cortical thickness and brain volume changes on 3 Tesla MRI of children with FLE and normal brain magnetic resonance imaging. Methods Twenty-seven children with FLE and 27 healthy controls received brain magnetic resonance imaging. Cortical thickness and regional brain volumes were assessed using three-dimensional volumetric T1-weighted imaging and patients were compared with controls. Results In children with FLE, statistically significant (p < 0.05) cortical thinning were found in the bilateral middle frontal gyrus, bilateral occipitotemporal and medial lingual gyrus, left subcallosal gyrus, left short insular gyrus, and right long insular gyrus. Statistically significant volume reductions in right and left hemisphere cortical white matter, total cortical white matter, bilateral thalamus, bilateral putamen, bilateral globus pallidus, right caudate nucleus, brain stem, and right cerebellar cortex were found. Conclusion Cortical thinning in frontal and extra-frontal lobes and volume loss in a variety of brain regions were found in children with FLE.
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Gemiler balıkları çiğner mi?
(1995) Karakuş, Hidayet
Open Access
Genetic investigation of idiopathic liver injury in children by whole exome sequencing
(2024-07) Lülecioğlu, Aysima Atılgan
Childhood liver diseases, caused by multiple etiologies, pose a significant burden globally. Liver injury of unknown causes remains a challenge in pediatric hepatology. For instance, the etiology remains unexplained in nearly half of the pediatric cases with acute liver failure. This ambiguity impedes early diagnosis and the timely consideration of treatment options. Recent studies, utilized by genome-wide approaches such as whole-exome sequencing (WES), reveal that idiopathic liver injury can be due to hitherto silent monogenic liver diseases. In our study, we aimed to investigate the monogenic determinants of idiopathic liver injury in children. We performed WES on 20 pediatric patients presenting with either recurrent elevated liver transaminases (rELT) of unknown etiology or indeterminate acute liver failure (ALF). We searched for potential disease-causing variants in a manually curated panel of 380 genes associated with inherited monogenic diseases with hepatobiliary phenotypes. We identified rare nonsynonymous variants in nine genes in total 6 patients, five rELT patients and one ALF patient. Then, we evaluated the causal concordance between the gene mutated and the clinical phenotype observed in each patient through an in-depth case-level assessment. Overall, we established a genetic diagnosis in four out of 10 rELT patients. We identified two novel mutations in ACOX2 and PYGL, expanding the spectrum of genetic mutations implicated in monogenic liver diseases. Additionally, we discovered two previously-reported morbid mutations in ABCB4 and PHKA2. Moreover, we identified five variants of uncertain significance (VUS) in CDAN1, JAG1, PCK2, SLC27A5, or VPS33B in rELT or ALF patients. This study further supports the utility of WES in clinical settings to enhance our understanding and management of idiopathic liver diseases in children, providing early diagnosis and precise treatment. By identifying the genetic variants contributing to liver injury, clinicians can predict disease progression more accurately, provide more personalized treatment strategies, and make decisions on liver transplantation when necessary.