Browsing by Subject "Cell dynamics"
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Item Unknown Local asymptotic stability conditions for the positive equilibrium of a system modeling cell dynamics in leukemia(Springer, Berlin, Heidelberg, 2012) Özbay, Hitay; Bonnet, C.; Benjelloun H.; Clairambault J.A distributed delay system with static nonlinearity has been considered in the literature to study the cell dynamics in leukemia. In this chapter local asymptotic stability conditions are derived for the positive equilibrium point of this nonlinear system. The stability conditions are expressed in terms of inequalities involving parameters of the system. These inequality conditions give guidelines for development of therapeutic actions. © 2012 Springer-Verlag GmbH Berlin Heidelberg.Item Open Access A new model of cell dynamics in Acute Myeloid Leukemia involving distributed delays(2012) Avila, J. L.; Bonnet, C.; Clairambault, J.; Özbay, Hitay; Niculescu, S. I.; Merhi, F.; Tang, R.; Marie, J. P.In this paper we propose a refined model for the dynamical cell behavior in Acute Myeloid Leukemia (AML) compared to (Özbay et al, 2012) and (Adimy et al, 2008).We separate the cell growth phase into a sequence of several sub-compartments. Then, with the help of the method of characteristics, we show that the overall dynamical system of equations can be reduced to two coupled nonlinear equations with four internal sub-systems involving distributed delays. © 2012 IFAC.Item Open Access Stability analysis of cell dynamics in leukemia(E D P Sciences, 2012) Özbay, Hitay; Bonnet, C.; Benjelloun, H.; Clairambault, J.In order to better understand the dynamics of acute leukemia, and in particular to find theoretical conditions for the efficient delivery of drugs in acute myeloblastic leukemia, we investigate stability of a system modeling its cell dynamics. The overall system is a cascade connection of sub-systems consisting of distributed delays and static nonlinear feedbacks. Earlier results on local asymptotic stability are improved by the analysis of the linearized system around the positive equilibrium. For the nonlinear system, we derive stability conditions by using Popov, circle and nonlinear small gain criteria. The results are illustrated with numerical examples and simulations.