Browsing by Subject "Benzylic amination"

Filter results by typing the first few letters
Now showing 1 - 2 of 2
  • Thumbnail Image
    ItemOpen Access
    Development of one-pot benzylic amination reactions of azine N-oxides
    (Elsevier, 2018) Liman, Menekşe; Türkmen, Yunus Emre
    An efficient one-pot synthetic methodology has been developed for the benzylic amination reactions of methyl-substituted azine N-oxides that operate under mild conditions. The reaction was found to tolerate quinoline and isoquinoline N-oxides with electron donating and withdrawing substituents as the electrophilic reaction partners as well as a broad range of nucleophilic primary, secondary and aromatic amines, affording the benzylic amination products in up to 82% yield.
  • Thumbnail Image
    ItemOpen Access
    One-pot, benzylic amination reactions of azine N-oxides
    (2017-06) Liman, Menekşe
    Nitrogen-containing aromatic heterocycles, found in many biologically active natural products and pharmaceutical drugs, constitute a highly important class of compounds in organic chemistry. In this context, areas such as the discoveries of new synthetic methods for both the synthesis and derivatization of nitrogen-containing heterocyclic compounds as well as for the introduction of nitrogen to a compound attract significant attention in the areas of organic and pharmaceutical chemistry. In this study, we have developed a new one-pot synthetic method for the benzylic amination of azine-N-oxides containing a methyl group at the 2-position. Following the optimization studies, the substrate scope of the developed reaction has been investigated in detail. The reaction tolerates quinoline and isoquinoline N-oxides with electron donating and withdrawing substituents as the electrophilic reaction partner as well as a broad range of nucleophilic primary, secondary and aromatic amines.