Browsing by Subject "Acoustophoresis"

Now showing 1 - 4 of 4

Open Access
3D modeling of on-chip acoustophoretic particle manipulation in a polymer microfluidic device
(Chemical and Biological Microsystems Society, 2016) Çaǧatay, E.; Özer, M. B.; Çetin, Barbaros
This study focuses on understanding of the sensitivities of the acoustophoretic process on uncertainties/errors in the geometric properties of the chip material and the piezoelectric actuators. The sensitivity of the acoustophoretic process is investigated both numerically and experimentally. For the numerical simulations a three dimensional finite element model is used. In the experimental analysis, a microfluidic chip with two stations is used. The first station has the accurate geometric values of the design and the second station has the introduced error in a geometric parameter so that the effect of this error can be demonstrated on the same chip and the channel.
Open Access
Investigation of effect of design and operating parameters on acoustophoretic particle separation via 3D device-level simulations
(Springer, 2020) Şahin, M. A.; Çetin, Barbaros; Özer, M. B.
In the present study, a 3D device-level numerical model is implemented via finite element method to assess the effects of design and operating parameters on the separation performance of a microscale acoustofluidic device. Elastodynamic equations together with electromechanical coupling at the piezoelectric actuators for the stress field within the solid parts, Helmholtz equation for the acoustic field within fluid, and Navier–Stokes equations for the fluid flow are coupled for the simulations. Once the zero-acoustic and flow fields are obtained, the trajectories of the particles are obtained by employing point–particle approach. The particle trajectories are simulated for many particles with different sizes released from random initial locations. Separation performances of the different cases are evaluated based on described metrics such as purity, yield, percentage of particle stuck in the channel, the force acting on the particles, residence time and separation parameter.
Open Access
Microscale acoustofluidics
(Springer, 2015) Çetin, Barbaros; Büyükkocak, S.; Özer, M. B.; Li, D.
Microscale acoustofluidics defines the use of ultrasonic waves onto a fluid inside a microchannel. The acoustic waves are imposed on the fluid through excitation of the microchannel walls with an actuator. Acoustofluidics in microchannels is commonly used for moving and manipulating microparticles in a microchannel.
Open Access
Numerical modeling of ultrasonic particle manipulation for microfluidic applications
(Springer Verlag, 2014) Büyükkoçak S.; Özer, M. B.; Çetin B.
A numerical simulation methodology for ultrasonic particle/cell separation and cell washing processes is introduced and validated by comparing with the results from the literature. In this study, a finite element approach is used for modeling fluid flow in a microchannel and analytical relations are utilized for the calculation of the ultrasonic radiation forces. The solutions in acoustic and fluidic domains are coupled, and the particle separation under the influence of ultrasonic waves is numerically simulated. In order to simulate the cell washing process, diffusion and fluid dynamics solutions are coupled and solved. A Monte Carlo approach is chosen where statistical distributions are implemented in the simulations. Uniform distributions for the starting locations of particles/cells in the microchannel and normal distributions for the size of the particles are used in numerical simulations. In each case, 750 particles are used for the simulation, and the performance of separation process is evaluated by checking how many microparticles resulted in the targeted outlet channels. Channel geometries for the numerical simulations are adapted from the experimental studies in literature, and comparison between the reported experimental results and the numerical estimations is performed. It has been observed that the numerical estimations and experimental results from the literature are in good agreement, and the proposed methodology may be implemented as a design tool for ultrasonic particle manipulation for microfluidic applications. © 2014, Springer-Verlag Berlin Heidelberg.