Browsing by Author "Uyar, Taha Bilal"

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Open Access
Metal ion release and signaling in molecular logic gate design
(2016-10) Uyar, Taha Bilal
Mimicking the biological structures is one of the main goals of the natural sciences, because processes are well-organized in nature despite its amazing complexity. On account of this, releasing metal ions at molecular level is a crucial topic owing to similar process in living organisms. In this thesis, we designed novel cage compounds for this purpose. Our novel cage molecule is activated with near-IR light while almost all of the cage compounds in the previous literature function in the UV region. Consequently, it is appropriate for using in biological systems. Release of zinc ions that has critical roles in human body successfully achieved by our novel compound in Part 2 of the thesis work. Molecular logic concept is one of the promising areas of chemistry. Today, electronic devices consists of silicon based circuits that process information by using binary logic. Molecular logic offers alternative for silicon based devices. Using molecules to process data is a promising idea in the fields from electronics to biotechnology. In part 3, we proposed AND gate whose inputs are pH and glutathione while the response is singlet oxygen which can be used to destroy cancer cells. It is possible to process much complicated information by combining more than one logic gate. In first part of the thesis study, we designed modular molecular logic gates by cascading of three logic gates via metal ion signals. In the last part, a fluorescent chemosensor was proposed for dopamine molecule, which is crucial in a number of biological processes at the human body.
Open Access
Synthesis and characterization of novel ion sensor based on 2, 6-functionalized BODIPY structure
(2012) Uyar, Taha Bilal
Latest developments in chemistry of BODIPY make available synthesis of novel BODIPY based fluorescent chemosensors. Therefore, the design of novel chemosensors is attracting great attention in recent years. In this study, we functionalized 2 and 6 positions of BODIPY choromophore to understand that binding of different metal ions how affect the absorption and emission spectrums of BODIPY. We used three metal ions which are important in environment and biological systems and these are Hg (II), Zn (II) and Ca ions. Binding of these metal ions to azo crown ether is which attached BODIPY caused large changes in absorption and emission spectrums according to photoinduced electron transfer (PET) and internal charge transfer (ICT) mechanism.