Browsing by Author "Puka, Beana"

Filter results by typing the first few letters
Now showing 1 - 2 of 2
  • Thumbnail Image
    ItemOpen Access
    Recent advances towards the understanding of secondary acute myeloid leukemia progression
    (MDPI AG, 2024-02-27) Auerbach, Scott; Puka, Beana; Golla, Upendarrao; Chachoua, Ilyas
    Secondary acute myeloid leukemia (sAML) is a heterogeneous malignant hematopoietic disease that arises either from an antecedent hematologic disorder (AHD) including myelodysplastic syndromes (MDS), myeloproliferative neoplasms (MPN), aplastic anemia (AA), or as a result of exposure to genotoxic chemotherapeutic agents or radiotherapy (therapy related AML, tAML). sAML is diagnosed when the number of blasts is ≥20% in the bone marrow or peripheral blood, and it is characterized by poor prognosis, resistance to therapy and low overall survival rate. With the recent advances in next generation sequencing technologies, our understanding of the molecular events associated with sAML evolution has significantly increased and opened new perspectives for the development of novel therapies. The genetic aberrations that are associated with sAML affect genes involved in processes such as splicing, chromatin modification and genome integrity. Moreover, non-coding RNAs’ emerged as an important contributing factor to leukemogenesis. For decades, the standard treatment for secondary AML has been the 7 + 3 regimen of cytarabine and daunorubicin which prolongs survival for several months, but modifications in either dosage or delivery has significantly extended that time. Apart from traditional chemotherapy, hematopoietic stem cell transplantation, CAR-T cell therapy and small molecule inhibitors have also emerged to treat sAML.
  • Thumbnail Image
    ItemRestricted
    The treaty of Lausanne and its significance
    (Bilkent University, 2020) Puka, Beana; Lim, Hyunwoong; Lim, Jiwoong; Kurmangazy, Saule; Jeong, Yewon
    The treaty of Lausanne is an important treaty that had finished the hostilities between the Ottoman Empire and the Allies, determining the borders of the modern Turkish Republic. By analyzing İsmet İnönü’s intensive negotiations on the treaty while Atatürk was doing successful battles in the Turkish lands, this paper aims to emphasize the importance of the treaty in the fate of the Turkish population’s history. Moreover, after the treaty was signed, by highlighting the celebrations done in Turkey on the Lausanne Day and especially the organizations in Halkevleri (People’s houses), this paper points out how Turkish population valued the treaty and considered it significant for their country’s history.