Browsing by Author "Konkle, J."
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Item Open Access Projection X-Space magnetic particle imaging(IEEE, 2012) Goodwill, P.; Konkle, J.; Zheng, B.; Sarıtaş, Emine Ülkü; Conolly, S.Projection magnetic particle imaging (MPI) can improve imaging speed by over 100-fold over traditional 3-D MPI. In this work, we derive the 2-D x-space signal equation, 2-D image equation, and introduce the concept of signal fading and resolution loss for a projection MPI imager. We then describe the design and construction of an x-space projection MPI scanner with a field gradient of 2.35 T/m across a 10 cm magnet free bore. The system has an expected resolution of 3.5 × 8.0 mm using Resovist tracer, and an experimental resolution of 3.8 × 8.4 mm resolution. The system images 2.5 cm × 5.0 cm partial field-of views (FOVs) at 10 frames/s, and acquires a full field-of-view of 10 cm × 5.0 cm in 4 s. We conclude by imaging a resolution phantom, a complex “Cal” phantom, mice injected with Resovist tracer, and experimentally confirm the theoretically predicted x-space spatial resolution.Item Open Access Twenty-fold acceleration of 3D projection reconstruction MPI(De Gruyter, 2013) Konkle, J.; Goodwill, P.; Sarıtaş, Emine Ülkü; Zheng, B.; Lu, K.; Conolly, S.We experimentally demonstrate a 20-fold improvement in acquisition time in projection reconstruction (PR) magnetic particle imaging (MPI) relative to the state-of-the-art PR MPI imaging results. We achieve this acceleration in our imaging system by introducing an additional Helmholtz electromagnet pair, which creates a slow shift (focus) field. Because of magnetostimulation limits in humans, we show that scan time with three-dimensional (3D) PR MPI is theoretically within the same order of magnitude as 3D MPI with a field free point; however, PR MPI has an order of magnitude signal-to-noise ratio gain.