Browsing by Author "Bila, Jose Luis"

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    Design, synthesis and characterization of orthogonal bodipy trimers and progress tpwards a singlet oxygen probe
    (2015-08) Bila, Jose Luis
    Several methods of fighting cancer have been proposed over the years after it was discovered. Photodynamic therapy (PDT) has been part of these methods for many years therefore; too much financial effort has been spent on this field. Since PDT relays on three important components namely: Sensitizer, molecular oxygen and light, our group has worked and published several photosensitizers derived from BODIPY over the years. In this thesis two different ideas to be used in PDT are introduced. First, Heavy atom free orthogonal BODIPY trimmers are introduced for the first time in literature and they are believed to work according to DS-TR principle. Effective singlet oxygen productions were obtained up to 0.53 quantum yields. The second topic is the use of BODIPY and 1,3-DiphenylIsobenzofuran hybrids as a singlet oxygen sensor. This sensor is meant to work based on PeT and ICT mechanisms. No further experimental methods were applied to this molecule after synthesis however; we intend to use it for in-vivo singlet oxygen experiments in the future.
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    Imaging of intracellular singlet oxygen with bright BODIPY dyes
    (Elsevier Ltd, 2021-04) Kaya, S.; Kwon, N.; Kim, G.; Bila, Jose Luis; İsmaiel, Yahya A.; Yoon, J.; Seven, Özlem; Akkaya, E.
    Singlet oxygen is a cytotoxic reactive species which is involved in the photodynamic therapy of cancer. It is also known to be produced endogenously in most eukaryotic cells and implicated in many biochemical processes, including apoptotic response. We now report that Bodipy based fluorescent dyes with singlet oxygen reactive modules, signal the intracellular generation of singlet oxygen through photosensitization. We believe long wavelength probes of singlet oxygen, based on this approach will be highly valuable.