Browsing by Author "Aslan, Yusuf"
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Item Restricted 1980’lerden itibaren İslami müzik ve İslami müziğin modernleşmesi: Grup Yeniçağ(Bilkent University, 2023) Arısan, Arda; Söylemezo, Berkay; Şevik, Dilara; Yıldız, Yiğit; Aslan, YusufBu makale, Türkiye’de 1980’lerden itibaren İslami müziğin modernleşme sürecini incelemektedir. İslami hareketin yükselişiyle birlikte, İslami müzik de dönüşüm geçirmiş ve farklı dönemlerden geçmiştir. Geleneksel İslami müzik formları, Batı müziğiyle birleştirilerek yeni bir tarz oluşturulmuştur. Grup Yeniçağ, bu modernleşme sürecinde öne çıkan gruplardan birisi olmuştur. Makalede, Grup Yeniçağ üyesi Ferhat Özgür Kale ile yapılan bir görüşme üzerine, Türkiye’de İslami müziğin modernleşme serüveni, dönemin özellikleri ve önemli aktörleri, modernleşmiş İslami müziğin toplumdaki yeri, akımın ve Türkiye’de geleneksel İslami müziğin tarihsel süreci ele alınmaktadır.Item Open Access Aptamer-based point-of-care devices: Emerging technologies and integration of computational methods(MDPI, 2023-05-22) Aslan, Yusuf; Atabay, Maryam; Chowdhury, Hussain Kawsar; Göktürk, Ilgım; Saylan, Y.; İnci, FatihRecent innovations in point-of-care (POC) diagnostic technologies have paved a critical road for the improved application of biomedicine through the deployment of accurate and affordable programs into resource-scarce settings. The utilization of antibodies as a bio-recognition element in POC devices is currently limited due to obstacles associated with cost and production, impeding its widespread adoption. One promising alternative, on the other hand, is aptamer integration, i.e., short sequences of single-stranded DNA and RNA structures. The advantageous properties of these molecules are as follows: small molecular size, amenability to chemical modification, low- or nonimmunogenic characteristics, and their reproducibility within a short generation time. The utilization of these aforementioned features is critical in developing sensitive and portable POC systems. Furthermore, the deficiencies related to past experimental efforts to improve biosensor schematics, including the design of biorecognition elements, can be tackled with the integration of computational tools. These complementary tools enable the prediction of the reliability and functionality of the molecular structure of aptamers. In this review, we have overviewed the usage of aptamers in the development of novel and portable POC devices, in addition to highlighting the insights that simulations and other computational methods can provide into the use of aptamer modeling for POC integration.Item Embargo Hybrid biosensing systems for the detection of biomolecules and disease biomarkers(2023-08) Aslan, YusufOptical metasurfaces are configurations of artificially structured surfaces designed to obtain unusual electromagnetic properties. The ability to manipulate a confined electromagnetic field enables metasurfaces to be utilized as optical point-of-care (POC) biosensors for the detection of low concentrations of biomarkers. Moreover, the integration of fluorescent molecules and plasmonic metasurfaces is utilized to enhance both plasmonic and fluorescent signals; however, the nanoscale distance and spectral overlap between the fluorescent emitter and plasmonic metasurface are crucial for the separation of the fluorescence-coupled plasmonic radiation and non-radiative induced plasmon surface entrapment. In this study, fluorescently labeled (FITC) proteins are integrated over a plasmonic metasurface via three different surface modifications for obtaining a hybrid biosensing system that boosts the device’s plasmonic sensitivity and lowers the detection limit. The metasurface is fabricated via physical vapor deposition of titanium (10 nm), silver (30 nm), and gold (15 nm), respectively over polycarbonate nanograting substrates of optical disks (DVDs). Additionally, the surface modifications are arranged via short-distance, medium-distance, and long-distance modifications for fluorescently labeled molecule binding. After the evaluations, the highest plasmonic wavelength shift over the FITC labeled protein binding is obtained from the medium-distance modification with ~4.4 times signal enhancement over the short-distance modification. The medium-distance modification is further combined with an immunoassay for the detection of Alzheimer’s disease. Consequently, this study paves the way for designing new arrangements on a metasurface to couple with fluorescence molecules while enhancing the analytical performance of the plasmonic biosensor.