Cu-catalyzed selective mono-N-pyridylation: Direct access to 2-aminoDMAP/sulfonamides as bifunctional organocatalysts

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dc.citation.epage1611en_US
dc.citation.issueNumber4en_US
dc.citation.spage1604en_US
dc.citation.volumeNumber78en_US
dc.contributor.authorIsik, M.en_US
dc.contributor.authorTanyeli, C.en_US
dc.date.accessioned2016-02-08T09:40:35Z
dc.date.available2016-02-08T09:40:35Z
dc.date.issued2013en_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.description.abstractDirect and selective mono-N-pyridylation of trans-(R,R)-cyclohexane-1,2- diamine is described here. Facile preparation of a novel chiral 2-aminoDMAP core catalaphore via Cu catalysis has led to the development of various sulfonamide/2-aminoDMAPs as bifunctional acid/base organocatalysts (most in two steps overall), which have been shown to very effectively promote asymmetric conjugate addition of acetylacetone to trans-β-nitroolefins with good to excellent yields (87-93%) and enantioselectivites (up to 99%). © 2013 American Chemical Society.en_US
dc.identifier.doi10.1021/jo302713ben_US
dc.identifier.issn223263
dc.identifier.urihttp://hdl.handle.net/11693/21071
dc.language.isoEnglishen_US
dc.relation.isversionofhttp://dx.doi.org/10.1021/jo302713ben_US
dc.source.titleJournal of Organic Chemistryen_US
dc.subjectAcetylacetoneen_US
dc.subjectAsymmetric conjugate additionen_US
dc.subjectBi-functionalen_US
dc.subjectCu catalysisen_US
dc.subjectEnantioselectivitesen_US
dc.subjectFacile preparationen_US
dc.subjectNitroolefinsen_US
dc.subjectOrganocatalystsen_US
dc.subjectAcetoneen_US
dc.subjectCatalysisen_US
dc.subjectCatalystsen_US
dc.subjectacetylacetoneen_US
dc.subjectcopperen_US
dc.subjectsulfonamideen_US
dc.subjectarticleen_US
dc.subjectcatalysisen_US
dc.subjectcatalysten_US
dc.subjectchemical reactionen_US
dc.subjectchiralityen_US
dc.subjectenantioselectivityen_US
dc.titleCu-catalyzed selective mono-N-pyridylation: Direct access to 2-aminoDMAP/sulfonamides as bifunctional organocatalystsen_US
dc.typeArticleen_US
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