Colon targeted delivery of niclosamide from β-cyclodextrin inclusion complex incorporated electrospun Eudragit® L100 nanofibers

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buir.contributor.authorAytaç, Zeynep
buir.contributor.authorYıldız, Zehra İrem
buir.contributor.authorUyar, Tamer
buir.contributor.orcidAytaç, Zeynep|0000-0002-6469-9653
buir.contributor.orcidYıldız, Zehra İrem|0000-0001-6220-6504
buir.contributor.orcidUyar, Tamer|0000-0002-3989-4481
dc.citation.epage111391-7en_US
dc.citation.spage111391-1en_US
dc.citation.volumeNumber197en_US
dc.contributor.authorÇoban, Ö.
dc.contributor.authorAytaç, Zeynep
dc.contributor.authorYıldız, Zehra İrem
dc.contributor.authorUyar, Tamer
dc.date.accessioned2022-01-28T11:41:46Z
dc.date.available2022-01-28T11:41:46Z
dc.date.issued2021-01
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.description.abstractElectrospun nanofibers incorporated with inclusion complex (IC) of niclosamide (NIC) and hydroxypropyl-beta-cyclodextrin (HPβCD) (NIC-HPβCD-IC) was produced from pH-responsive polymer (Eudragit® L100, EUD), which disintegrates at pH values higher than 6, (EUD-NIC-HPβCD-IC-NF) for targeted delivery of NIC to the colon. Pristine EUD nanofibers (EUD-NF), only NIC loaded (EUD-NIC-NF) and physical mixture of NIC and HPβCD loaded EUD nanofibers (EUD-NIC-HPβCD-NF) were also produced as reference. SEM images revealed the bead-free and uniform morphology of nanofibers. XRD, TGA, and DSC were also performed for both NIC-HPβCD-IC and electrospun nanofibers and it was seen that there are some NIC molecules, which cannot make IC. Dissolution studies were carried out for 240 min at pH 1.2 and pH 7 simulating stomach and colon, respectively. EUD-NIC-NF released almost 53 % of NIC in 120 min, whereas EUD-NIC-HPβCD-NF (15 %) and EUD-NIC-HPβCD-IC-NF (8 %) released at most 15 % of NIC in 120 min. Then, remained NIC in the nanofibers released into the colon for the next 120 min. The slight difference in the release of NIC into stomach from EUD-NIC-HPβCD-NF and EUD-NIC-HPβCD-IC-NF might be due to the uncomplexed NIC molecules in EUD-NIC-HPβCD-IC-NF. More importantly, EUD-NIC-HPβCD-IC-NF was quite effective for preventing the release of NIC in the stomach in contrast to EUD-NIC-NF, which has already released more than half amount of NIC in 120 min. In conclusion, this study might open new areas for developing targeted delivery systems by the combination of nanofibers and CD-ICs for hydrophobic drugs such as NIC.en_US
dc.embargo.release2023-01-31
dc.identifier.doi10.1016/j.colsurfb.2020.111391en_US
dc.identifier.issn1873-4367
dc.identifier.urihttp://hdl.handle.net/11693/76874
dc.language.isoEnglishen_US
dc.publisherElsevier BVen_US
dc.relation.isversionofhttps://doi.org/10.1016/j.colsurfb.2020.111391en_US
dc.source.titleColloids and Surfaces B: Biointerfacesen_US
dc.subjectNiclosamideen_US
dc.subjectCyclodextrinen_US
dc.subjectEudragit® L100en_US
dc.subjectElectrospinningen_US
dc.subjectNanofiberen_US
dc.titleColon targeted delivery of niclosamide from β-cyclodextrin inclusion complex incorporated electrospun Eudragit® L100 nanofibersen_US
dc.typeArticleen_US
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