Fast-dissolving antibacterial nanofibers of cyclodextrin/antibiotic inclusion complexes for oral drug delivery

Simple item page
buir.contributor.authorDurgun, Engin
dc.citation.epage194en_US
dc.citation.spage184en_US
dc.citation.volumeNumber585en_US
dc.contributor.authorTopuz, F.
dc.contributor.authorKılıç, M. E.
dc.contributor.authorDurgun, Engin
dc.date.accessioned2021-03-10T07:24:32Z
dc.date.available2021-03-10T07:24:32Z
dc.date.issued2020
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.description.abstractHypothesis The widespread use of antibacterial electrospun nanofibers is mostly restricted due to their low loading capacity to carry antibiotics and the need to use toxic organic solvents to boost the antibiotic loading capacity. Nanofibers based on natural excipients, such as cyclodextrin (CD)-based nanofibers, can carry larger amounts of antibiotics while achieving better stability via inclusion complexation. Experiments Nanofibers were produced by electrospinning and analyzed by electron microscopy to investigate the morphology of fibers. The formation of inclusion-complexation was analyzed by 1H NMR, FTIR, and XRD. Thermal analysis of the fibers was done using TGA. Ab initio modeling studies were done to calculate the complexation energies of antibiotics with CD. A disk-diffusion assay was used to test the antibacterial activity of the fibers. Findings Bead-free antibacterial nanofibers with mean diameters between 340 and 550 nm were produced. The formation of inclusion complexes (IC) between the CD and the antibiotics was confirmed by FTIR and 1H NMR, which was further verified by the disappearance of the crystalline peaks of antibiotics as determined by XRD analysis. Thermal analysis of the nanofibers revealed that the formulations showed good antibiotic encapsulation (45–90%). Ab initio simulations revealed that gentamicin had the highest complexation energy, followed by kanamycin, chloramphenicol, and ampicillin. The antibacterial nanofibers rapidly dissolved in water and artificial saliva, successfully releasing the CD antibiotic complexes. The nanofibers showed high antibacterial activity against Gram-negative Escherichia coli.en_US
dc.embargo.release2023-03-01
dc.identifier.doi10.1016/j.jcis.2020.11.072en_US
dc.identifier.issn0021-9797
dc.identifier.urihttp://hdl.handle.net/11693/75907
dc.language.isoEnglishen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttps://doi.org/10.1016/j.jcis.2020.11.072en_US
dc.source.titleJournal of Colloid and Interface Scienceen_US
dc.subjectElectrospinningen_US
dc.subjectCyclodextrinen_US
dc.subjectInclusion complex (IC)en_US
dc.subjectAntibacterial nanofibersen_US
dc.subjectAntibioticsen_US
dc.subjectOral drug deliveryen_US
dc.titleFast-dissolving antibacterial nanofibers of cyclodextrin/antibiotic inclusion complexes for oral drug deliveryen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Fast-dissolving_antibacterial_nanofibers_of_cyclodextrin_antibiotic_inclusion_complexes_for_oral_drug_delivery.pdf
Size:
5.06 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Institute of Materials Science and Nanotechnology (UNAM)