NAPO as a novel apoptosis marker

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buir.supervisorÖztürk, Mehmet
dc.contributor.authorSayan, Berna S.
dc.date.accessioned2016-01-08T20:19:41Z
dc.date.available2016-01-08T20:19:41Z
dc.date.issued2002
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.descriptionCataloged from PDF version of article.
dc.descriptionAnkara : The Department of Molecular Biology and Genetics and the Institute of Engineering and Science of Bilkent Univ., 2002.en_US
dc.descriptionThesis (Ph. D.) -- Bilkent University, 2002.en_US
dc.descriptionIncludes bibliographical references (leaves 112-129).en_US
dc.description.abstractApoptosis or programmed cell death plays a pivotal role in embryonic development and maintenance of homeostasis. It is also involved in the etiology of pathophysiological conditions such as cancer, neurodegenerative, autoimmune, infectious and heart diseases. Consequently, the study of apoptosis is now at center of both basic and clinical research applications. Therefore sensitive and simple apoptosis detection techniques are required. This study involves identification and characterization of a monoclonal antibody-defined novel antigen, namely NAPO (negative in apoptosis), which is specifically lost during apoptosis. The anti-NAPO antibody recognizes two nuclear polypeptides of 60 kD and 70 kD. The antigen is maintained in quiescent and senescent cells, as well as in different phases of the cell cycle including mitosis. Thus, immunodetection of NAPO antigen provides a specific, sensitive and easy method for differential identification of apoptotic and non-apoptotic cells.
dc.description.degreePh.D.en_US
dc.description.statementofresponsibilityby Berna S. Sayanen_US
dc.format.extentxx, 129 leaves, [17] leaves appendix : illustrations ; 30 cm.en_US
dc.identifier.itemidB067490
dc.identifier.urihttp://hdl.handle.net/11693/18478
dc.language.isoEnglishen_US
dc.publisherBilkent Universityen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleNAPO as a novel apoptosis markeren_US
dc.title.alternativeYeni bir apoptoz belirteci: NAPO
dc.typeThesisen_US
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