In many inverse problems of signal processing the problem reduces to a linear system of equations. Accurate and robust estimation of the solution with errors in both measurement vector and coefficient matrix is a challenging task. In this paper a novel formulation is proposed which takes into account the structure (e.g. Toeplitz, Hankel) and uncertainties of the system. A numerical algorithm is provided to obtain the solution. The proposed technique and other methods are compared in a channel equalization example which is a fundamental necessity in communication.