Core-shell nanofibers of curcumin/cyclodextrin inclusion complex and polylactic acid: enhanced water solubility and slow release of curcumin

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buir.contributor.orcidUyar, Tamer|0000-0002-3989-4481
dc.citation.epage184en_US
dc.citation.issueNumber1-2en_US
dc.citation.spage177en_US
dc.citation.volumeNumber518en_US
dc.contributor.authorAytaç, Zeynepen_US
dc.contributor.authorUyar, Tameren_US
dc.date.accessioned2018-04-12T11:11:50Z
dc.date.available2018-04-12T11:11:50Z
dc.date.issued2017-02en_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.departmentNanotechnology Research Center (NANOTAM)en_US
dc.description.abstractCore-shell nanofibers were designed via electrospinning using inclusion complex (IC) of model hydrophobic drug (curcumin, CUR) with cyclodextrin (CD) in the core and polymer (polylactic acid, PLA) in the shell (cCUR/HPβCD-IC-sPLA-NF). CD-IC of CUR and HPβCD was formed at 1:2 molar ratio. The successful formation of core-shell nanofibers was revealed by TEM and CLSM images. cCUR/HPβCD-IC-sPLA-NF released CUR slowly but much more in total than PLA-CUR-NF at pH 1 and pH 7.4 due to the restriction of CUR in the core of nanofibers and solubility improvement shown in phase solubility diagram, respectively. Improved antioxidant activity of cCUR/HPβCD-IC-sPLA-NF in methanol:water (1:1) is related with the solubility enhancement achieved in water based system. The slow reaction of cCUR/HPβCD-IC-sPLA-NF in methanol is associated with the shell inhibiting the quick release of CUR. On the other hand, cCUR/HPβCD-IC-sPLA-NF exhibited slightly higher rate of antioxidant activity than PLA-CUR-NF in methanol:water (1:1) owing to the enhanced solubility. To conclude, slow release of CUR was achieved by core-shell nanofiber structure and inclusion complexation of CUR with HPβCD provides high solubility. Briefly, electrospinning of core-shell nanofibers with CD-IC core could offer slow release of drugs as well as solubility enhancement for hydrophobic drugs.en_US
dc.identifier.doi10.1016/j.ijpharm.2016.12.061en_US
dc.identifier.issn0378-5173
dc.identifier.urihttp://hdl.handle.net/11693/37381
dc.language.isoEnglishen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttps://doi.org/10.1016/j.ijpharm.2016.12.061en_US
dc.source.titleInternational Journal of Pharmaceuticsen_US
dc.subjectAntioxidant activityen_US
dc.subjectCore-shellen_US
dc.subjectCurcuminen_US
dc.subjectElectrospinningen_US
dc.subjectHydroxypropyl-β-cyclodextrinen_US
dc.subjectSlow releaseen_US
dc.titleCore-shell nanofibers of curcumin/cyclodextrin inclusion complex and polylactic acid: enhanced water solubility and slow release of curcuminen_US
dc.typeArticleen_US
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Nanotechnology Research Center (NANOTAM)