Electrospinning of cyclodextrin functionalized nanofibers and their applications

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buir.advisorUyar, Tamer
dc.contributor.authorAytaç, Zeynep
dc.date.accessioned2016-09-05T13:20:24Z
dc.date.available2016-09-05T13:20:24Z
dc.date.copyright2016-08
dc.date.issued2016-08
dc.date.submitted2016-09-01
dc.departmentGraduate Program in Materials Science and Nanotechnologyen_US
dc.descriptionCataloged from PDF version of article.en_US
dc.descriptionThesis (Ph.D.): Bilkent University, Department of Materials Science and Nanotechnology, İhsan Doğramacı Bilkent University, 2016.en_US
dc.descriptionIncludes bibliographical references (leaves 201-230).en_US
dc.description.abstractElectrospinning is a widely used versatile method to produce nanofibers with high surface to volume ratio and porous structure. Owing to the unique properties, electrospun nanofibers are of great importance as a carrier matrix for drugs; antioxidant, and antibacterial agents, flavour/fragrances. Though polymers are material of choice for producing electrospun nanofibers, it is likely to obtain nanofibers from low molecular weight molecules. Cyclodextrin (CDs) are intriguing molecules having the capability of forming inclusion complex (IC) with numerous guest molecules such as drugs, food additives, flavour/fragrances, antioxidant and antibacterial agents. Therefore, CD-ICs enhance solubility, reduce volatility, and provide controlled release of the guest molecules. Integrating CD-ICs with electrospinning opens a new door to produce remarkable materials. In this thesis, nanofibers containing CD-ICs of bioactive agents including antioxidant/antibacterial and flavour/fragrance molecules were produced via electrospinning technique. Firstly, CD-ICs of antioxidant/antibacterial compounds (gallic acid, α-tocopherol, quercetin, and thymol) were synthesized and then, added into polylactic acid or zein solutions to produce CD-IC incorporated electrospun polymeric nanofibers. Afterwards, the release behavior, antioxidant and antibacterial activity of these nanofibers were investigated. In addition, the potential use of these nanofibers as active food packaging and delivery material was revealed by packing meat samples by these nanofibers. Secondly, electrospun nanofibers were developed as a releasing material from CD-ICs of volatile flavour/fragrance molecules (geraniol, limonene, and linalool) without using polymeric matrix. The preservation of volatile compounds is shown to be possible to a great extent with antibacterial CD-IC nanofibers. Furthermore, the shelf life of flavour/fragrance molecules has been enhanced at least 50 days by CD-IC nanofibers. Finally, for the first time in the literature core-shell nanofibers were designed by using CD-IC of curcumin, an antioxidant molecule and polylactic acid solutions as core and shell, respectively. The ability of core-shell nanofibers as a drug delivery carrier was suggested by release and antioxidant activity tests. To conclude, CD-IC incorporated electrospun nanofibers produced by three different approach is shown to be used as efficient material for various applications particularly for food packaging and drug delivery.en_US
dc.description.degreePh.D.en_US
dc.description.statementofresponsibilityby Zeynep Aytaç.en_US
dc.embargo.release2018-09-01
dc.format.extentxxiv, 230 leaves : illustrations (some color), charts.en_US
dc.identifier.itemidB154003
dc.identifier.urihttp://hdl.handle.net/11693/32199
dc.language.isoEnglishen_US
dc.publisherBilkent Universityen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectElectrospinningen_US
dc.subjectNanofiberen_US
dc.subjectPolylactic aciden_US
dc.subjectZeinen_US
dc.subjectCore-shell nanofibersen_US
dc.subjectCyclodextrinen_US
dc.subjectInclusion complexen_US
dc.subjectAntioxidanten_US
dc.subjectAntibacterialen_US
dc.subjectFlavour/fragranceen_US
dc.subjectFood packagingen_US
dc.subjectDrug deliveryen_US
dc.titleElectrospinning of cyclodextrin functionalized nanofibers and their applicationsen_US
dc.title.alternativeElektroeğirme yöntemi ile üretilen siklodekstrin fonksiyonlu nanolifler ve uygulama alanlarıen_US
dc.typeThesisen_US
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