Cooperative effect of heparan sulfate and laminin mimetic peptide nanofibers on the promotion of neurite outgrowth

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buir.contributor.authorMammadov, Busra
buir.contributor.authorMammadov, Rashad
buir.contributor.authorGüler, Mustafa O.
buir.contributor.authorTekinay, Ayse B.
dc.citation.epage2086en_US
dc.citation.issueNumber6en_US
dc.citation.spage2077en_US
dc.citation.volumeNumber8en_US
dc.contributor.authorMammadov, Busraen_US
dc.contributor.authorMammadov, Rashaden_US
dc.contributor.authorGüler, Mustafa O.en_US
dc.contributor.authorTekinay, Ayse B.en_US
dc.date.accessioned2016-02-08T09:46:04Z
dc.date.available2016-02-08T09:46:04Z
dc.date.issued2012en_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.departmentAysel Sabuncu Brain Research Center (BAM)en_US
dc.description.abstractExtracellular matrix contains an abundant variety of signals that are received by cell surface receptors contributing to cell fate, via regulation of cellular activities such as proliferation, migration and differentiation. Cues from extracellular matrix can be used for the development of materials to direct cells into their desired fate. Neural extracellular matrix (ECM) is rich in axonal growth inducer proteins, and by mimicking these permissive elements in the cellular environment, neural differentiation as well as neurite outgrowth can be induced. In this paper, we used a synthetic peptide nanofiber system that can mimic not only the activity of laminin, an axonal growth-promoting constituent of the neural ECM, but also the activity of heparan sulfate proteoglycans in order to induce neuritogenesis. Heparan sulfate mimetic groups that were utilized in our system have an affinity to growth factors and induce the neuroregenerative effect of laminin mimetic peptide nanofibers. The self-assembled peptide nanofibers with heparan sulfate mimetic and laminin-derived epitopes significantly promoted neurite outgrowth by PC-12 cells. In addition, these scaffolds were even effective in the presence of chondroitin sulfate proteoglycans (CSPGs), which are the major inhibitory components of the central nervous system. In the presence of these nanofibers, cells could overcome CSPG inhibitory effect and extend neurites on peptide nanofiber scaffolds. © 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.actbio.2012.02.006en_US
dc.identifier.issn1742-7061
dc.identifier.urihttp://hdl.handle.net/11693/21420
dc.language.isoEnglishen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.actbio.2012.02.006en_US
dc.source.titleActa Biomaterialiaen_US
dc.subjectNeural differentiationen_US
dc.subjectPC-12 cellsen_US
dc.subjectPeptide amphiphilesen_US
dc.subjectLaminin mimeticen_US
dc.subjectHeparan sulfate mimeticen_US
dc.titleCooperative effect of heparan sulfate and laminin mimetic peptide nanofibers on the promotion of neurite outgrowthen_US
dc.typeArticleen_US
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Institute of Materials Science and Nanotechnology (UNAM)
Aysel Sabuncu Brain Research Center (BAM)
Nanotechnology Research Center (NANOTAM)