Facilitated polymer capture by charge inverted electroosmotic flow in voltage-driven polymer translocation

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buir.contributor.authorBüyükdağlı, Şahin
dc.citation.epage3549en_US
dc.citation.issueNumber18en_US
dc.citation.spage3541en_US
dc.citation.volumeNumber14en_US
dc.contributor.authorBüyükdağlı, Şahinen_US
dc.date.accessioned2019-02-21T16:02:53Z
dc.date.available2019-02-21T16:02:53Z
dc.date.issued2018en_US
dc.departmentDepartment of Physicsen_US
dc.description.abstractThe optimal functioning of nanopore-based biosensing tools necessitates rapid polymer capture from the ion reservoir. We identify an ionic correlation-induced transport mechanism that provides this condition without the chemical modification of the polymer or the pore surface. In the typical experimental configuration where a negatively charged silicon-based pore confines a 1:1 electrolyte solution, anionic polymer capture is limited by electrostatic polymer-membrane repulsion and the electroosmotic (EO) flow. Added multivalent cations suppress the electrostatic barrier and reverse the pore charge, inverting the direction of the EO flow that drags the polymer to the trans side. This inverted EO flow can be used to speed up polymer capture from the reservoir and to transport weakly or non-uniformly charged polymers that cannot be controlled by electrophoresis.
dc.identifier.doi10.1039/c8sm00620b
dc.identifier.issn1744-683X
dc.identifier.urihttp://hdl.handle.net/11693/50052
dc.language.isoEnglish
dc.publisherRoyal Society of Chemistry
dc.relation.isversionofhttps://doi.org/10.1039/c8sm00620b
dc.source.titleSoft Matteren_US
dc.titleFacilitated polymer capture by charge inverted electroosmotic flow in voltage-driven polymer translocationen_US
dc.typeArticleen_US
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