Zebrafish xenotransplantation models for studying gene function and drug treatment in hepatocellular carcinoma

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buir.contributor.authorTargen, Seniye
buir.contributor.authorKonu, Ozlen
dc.citation.epage1265en_US
dc.citation.issueNumber4en_US
dc.citation.spage1248en_US
dc.citation.volumeNumber52en_US
dc.contributor.authorKonu, Ozlen
dc.contributor.authorTargen, Seniye
dc.date.accessioned2023-02-15T11:16:29Z
dc.date.available2023-02-15T11:16:29Z
dc.date.issued2022-01-15
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.description.abstractIntroduction Zebrafish is a promising model organism for human disease including hepatocellular cancer (HCC). Recently, zebrafish has emerged also as a host for xenograft studies of liver cancer cell lines and patient derived tumors of HCC. Zebrafish embryos enable drug screening and gene function studies of xenografted cells via ease of microinjection and visualization of tumor growth and metastasis. Objectives In this review, we aimed to overview zebrafish HCC and liver cancer xenotransplantation studies focusing on ‘gene functional analysis’ and ‘drug/chemical screening’. Methods Herein, a comprehensive literature search was performed for liver and HCC xenografts in zebrafish on PubMed using different key words and filters for molecular modifications or drug exposure. Results Our literature search revealed around 250 studies which were filtered and summarized in a table (Table 1) revealing comprehensive collection of experimental and technical details on microinjection, injected cell lines, molecular modifications of injected cells, types and doses of drug treatments as well as biological assessments. Conclusion This review provides a platform for HCC and liver xenografts and highlights studies performed to understand gene functionality and drug efficacy in vivo in zebrafish.en_US
dc.identifier.doi10.1007/s12029-021-00782-zen_US
dc.identifier.urihttp://hdl.handle.net/11693/111336
dc.language.isoEnglishen_US
dc.relation.isversionofhttps://www.doi.org/10.1007/s12029-021-00782-zen_US
dc.source.titleJournal of Gastrointestinal Canceren_US
dc.subjectZebrafshen_US
dc.subjectGene functionen_US
dc.subjectHCCen_US
dc.subjectXenograften_US
dc.titleZebrafish xenotransplantation models for studying gene function and drug treatment in hepatocellular carcinomaen_US
dc.typeArticleen_US
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