The effect of SARS-CoV-2 virus on resting-state functional connectivity during adolescence: Investigating brain correlates of psychotic-like experiences and SARS-CoV-2 related inflammation response

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buir.contributor.authorDasgin, Hacer
buir.contributor.authorSahin Cevik, Didenur
buir.contributor.authorOguz, Kader K.
buir.contributor.authorToulopoulou, Timothea
buir.contributor.orcidOguz, Kader K.|0000-0002-3385-4665
dc.citation.epage111746-8en_US
dc.citation.spage111746-1
dc.citation.volumeNumber336
dc.contributor.authorYilmaz Kafali, H.
dc.contributor.authorDasgin, Hacer
dc.contributor.authorSahin Cevik, Didenur
dc.contributor.authorSozan, S. S.
dc.contributor.authorOguz, Kader K.
dc.contributor.authorMutlu, M.
dc.contributor.authorOzkaya Parlakay, A.
dc.contributor.authorToulopoulou, Timothea
dc.date.accessioned2024-03-11T05:54:01Z
dc.date.available2024-03-11T05:54:01Z
dc.date.issued2023-12
dc.departmentNational Magnetic Resonance Research Center (UMRAM)
dc.departmentDepartment of Philosophy
dc.description.abstractWe first aimed to investigate resting-state functional connectivity (rs-FC) differences between adolescents exposed to SARS-CoV-2 and healthy controls. Secondly, the moderator effect of PLEs on group differences in rs-FC was examined. Thirdly, brain correlates of inflammation response during acute SARS-CoV-2 infection were investigated. Eighty-two participants aged between 14 and 24 years (SARS-CoV-2 (n = 35), controls (n = 47)) were examined using rs-fMRI. Seed-based rs-FC analysis was performed. The positive subscale of Community Assessment of Psychotic Experiences-42 (CAPE-Pos) was used to measure PLEs. The SARS-CoV-2 group had a lesser rs-FC within sensorimotor network (SMN), central executive network (CEN) and language network (LN), but an increased rs-FC within visual network (VN) compared to controls. No significant differences were detected between the groups regarding CAPE-Pos-score. However, including CAPE-Pos as a covariate, we found increased rs-FC within CEN and SN in SARS-CoV-2 compared to controls. Among the SARS-CoV-2 group, neutrophil/lymphocyte and thrombocyte*neutrophil/lymphocyte ratio was correlated with decreased/increased FC within DMN and SN, and increased FC within CEN. Our results showed rs-FC alterations within the SMN, CEN, LN, and VN among adolescents exposed to SARS-CoV-2. Moreover, changes in rs-FC associated with PLEs existed in these adolescents despite the absence of clinical changes. Furthermore, inflammation response was correlated with alterations in FC within the triple network system.
dc.identifier.doi10.1016/j.pscychresns.2023.111746
dc.identifier.eissn1872-7506
dc.identifier.issn0925-4927
dc.identifier.urihttps://hdl.handle.net/11693/114465
dc.language.isoen_US
dc.publisherElsevier B.V.
dc.relation.isversionofhttps://doi.org/10.1016/j.pscychresns.2023.111746
dc.rightsCC BY 4.0 Deed (Attribution 4.0 International)
dc.rights.urihttps://creativecommons.org/licenses/by/2.0/
dc.source.titlePsychiatry Research: Neuroimaging
dc.subjectCOVID-19
dc.subjectPsychosis proneness
dc.subjectNeuroimaging
dc.subjectFunctional connectivity
dc.subjectAdolescent
dc.subjectInflammation markers
dc.subjectBrain networks
dc.titleThe effect of SARS-CoV-2 virus on resting-state functional connectivity during adolescence: Investigating brain correlates of psychotic-like experiences and SARS-CoV-2 related inflammation response
dc.typeArticle
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