Neuroactive peptide nanofibers for regeneration of spinal cord after injury

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buir.contributor.authorSever-Bahçekapılı, Melike
buir.contributor.authorYılmaz, Canelif
buir.contributor.authorTekinay, Ayşe Begüm
buir.contributor.orcidSever-Bahçekapılı, Melike|0000-0002-0592-9666
buir.contributor.orcidYılmaz, Canelif|0000-0002-9676-9310
buir.contributor.orcidTekinay, Ayşe Begüm|0000-0002-4453-814X
dc.citation.epage2000234-9en_US
dc.citation.issueNumber1en_US
dc.citation.spage2000234-1en_US
dc.citation.volumeNumber21en_US
dc.contributor.authorSever-Bahçekapılı, Melike
dc.contributor.authorYılmaz, Canelif
dc.contributor.authorDemirel, A.
dc.contributor.authorKilinc, M. C.
dc.contributor.authorDogan, I.
dc.contributor.authorCaglar, Y. S.
dc.contributor.authorGuler, M. O.
dc.contributor.authorTekinay, Ayşe Begüm
dc.date.accessioned2022-03-01T06:54:06Z
dc.date.available2022-03-01T06:54:06Z
dc.date.issued2020-10-11
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.description.abstractThe highly complex nature of spinal cord injuries (SCIs) requires design of novel biomaterials that can stimulate cellular regeneration and functional recovery. Promising SCI treatments use biomaterial scaffolds, which provide bioactive cues to the cells in order to trigger neural regeneration in the spinal cord. In this work, the use of peptide nanofibers is demonstrated, presenting protein binding and cellular adhesion epitopes in a rat model of SCI. The self-assembling peptide molecules are designed to form nanofibers, which display heparan sulfate mimetic and laminin mimetic epitopes to the cells in the spinal cord. These neuroactive nanofibers are found to support adhesion and viability of dorsal root ganglion neurons as well as neurite outgrowth in vitro and enhance tissue integrity after 6 weeks of injury in vivo. Treatment with the peptide nanofiber scaffolds also show significant behavioral improvement. These results demonstrate that it is possible to facilitate regeneration especially in the white matter of the spinal cord, which is usually damaged during the accidents using bioactive 3D nanostructures displaying high densities of laminin and heparan sulfate-mimetic epitopes on their surfaces.en_US
dc.embargo.release2021-10-11
dc.identifier.doi10.1002/mabi.202000234en_US
dc.identifier.eissn1616-5195
dc.identifier.urihttp://hdl.handle.net/11693/77631
dc.language.isoEnglishen_US
dc.publisherWiley-VCH Verlag GmbH & Co. KGaAen_US
dc.relation.isversionofhttps://doi.org/10.1002/mabi.202000234en_US
dc.source.titleMacromolecular Bioscienceen_US
dc.subjectExtracellular matrixen_US
dc.subjectGlycosaminoglycanen_US
dc.subjectLamininen_US
dc.subjectPeptide nanofibersen_US
dc.subjectSpinal cord regenerationen_US
dc.titleNeuroactive peptide nanofibers for regeneration of spinal cord after injuryen_US
dc.typeArticleen_US
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