Sulfatide and its synthetic analogues recognition by Moraxella catarrhalis

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dc.citation.epage970en_US
dc.citation.issueNumber12en_US
dc.citation.spage967en_US
dc.citation.volumeNumber50en_US
dc.contributor.authorOzcelik, P.en_US
dc.contributor.authorBezirci, F. B.en_US
dc.contributor.authorSuzuki, Y.en_US
dc.contributor.authorUzawa, H.en_US
dc.contributor.authorNishida, Y.en_US
dc.contributor.authorKobayashi, K.en_US
dc.contributor.authorSuzuki, T.en_US
dc.contributor.authorMiyamoto, D.en_US
dc.contributor.authorNagatake, T.en_US
dc.contributor.authorAhmed, K.en_US
dc.date.accessioned2016-02-08T10:16:06Z
dc.date.available2016-02-08T10:16:06Z
dc.date.issued2006en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.description.abstractMoraxella catarrhalis is one of the major pathogens of respiratory and middle ear infections. Attachment of this bacterium to the surface of human pharyngeal epithelial cells is the first step in the pathogenesis of infections. This study revealed that sulfatide might act as a binding molecule for the attachment of M. catarrhalis to human pharyngeal epithelial cells. Furthermore, six different synthetic sulfatides were found to inhibit the attachment of M. catarrhalis significantly at an optimum concentration of 10 μg/ml. Synthetic sulfatides may have the potential to be used as a therapy to prevent M. catarrhalis infections.en_US
dc.identifier.issn0385-5600
dc.identifier.urihttp://hdl.handle.net/11693/23590
dc.language.isoEnglishen_US
dc.publisherSpringeren_US
dc.source.titleMicrobiology and Immunologyen_US
dc.subjectAttachmenten_US
dc.subjectHuman pharyngeal epithelial cellen_US
dc.subjectMoraxella catarrhalisen_US
dc.subjectSulfatideen_US
dc.titleSulfatide and its synthetic analogues recognition by Moraxella catarrhalisen_US
dc.typeArticleen_US
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