This thesis investigates a homogenization-based space-time optimization framework in the context of hydrodynamic lubrication in order to design micro-textures which can be actively controlled through external stimuli. The response at the interface is established via the Reynolds equation to describe the physics of the lubrication for a small film thickness. Subsequently, the interface is subjected to multiscale analysis and effective macroscopic parameters are derived via homogenization method. In order to calculate the macroscopic parameters, Finite Element (FE) formulation is employed and the implementation of the parameters in the in-house FE code is demonstrated. For the suboptimality problem due to typically employed fixed unit cell in FE analysis, a geometry optimization scheme is developed. Thereafter, a sensitivity based topology optimization framework is introduced with the aim of identifying the spatial distribution and temporal variation of the micro-texture, and the shape of the unit cell which together help achieve the targeted lubrication response. The performance of the employed framework is assessed through objectives which ultimately determine the macroscopic flux at the interface as well as the frictional traction that is associated with the macroscopic dissipation at the interface. Finally, three-dimensional realizations are constructed for active micro-textures by adopting a readily deployable experimental architecture.